Bacteriocin: Enterocin AS-48 (BACTERIOCIN AS-48)

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Bacteriocin: Enterocin AS-48 (BACTERIOCIN AS-48)

Accession: BAC143

Classification
Class: Unclassified
Genetics
Gene: as-48
Description
The antimicrobial effect of AS-48 is due to its ability to form pores in the membranes of sensitive bacteria, leading to the efflux of small molecules and the depletion of the membrane electrical potential and ultimately leading to cell death
NUCLEOTIDE SEQUENCE, STRAIN=S-48; PLASMID=BglII;
MEDLINE=95014079;PubMed=7929005;
Martinez-Bueno M., Maqueda M., Galvez A., Samyn B., Van Beeumen J., Coyette J., Valdivia E.
"Determination of the gene sequence and the molecular structure of the enterococcal peptide antibiotic AS-48.", J. Bacteriol. 176:6334-6339(1994).
PROTEIN SEQUENCE, PLASMID=BglII;
MEDLINE=95010683;PubMed=7925951;DOI=10.1016/0014-5793(94)00925-2
Samyn B., Martinez-Bueno M., Devreese B., Maqueda M., Galvez A., Valdivia E., Coyette J., Van Beeumen J.
"The cyclic structure of the enterococcal peptide antibiotic AS-48.", FEBS Lett. 352:87-90(1994).
PROTEIN STRUCTURE
Gonzalez, C., Langdon, G.M., Bruix, M., Galvez, A., Valdivia, E., Maqueda, M., Rico, M.
"Bacteriocin AS-48, a microbial cyclic polypeptide structurally and functionally related to mammalian NK-lysin.", Proc.Natl.Acad.Sci.USA (2000) 97: 11221-11226.
Characterization of AS-48
PubMed=3098396;
Gálvez A., Maqueda M., Valdivia E., Quesada A., Montoya E.
"Characterization and partial purification of a broad spectrum antibiotic AS-48 produced by Streptococcus faecalis.", Can. j. Microbiol. 32(10):765-771(1986)
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Gene structure
genome of Enterocin AS-48 (BACTERIOCIN AS-48)

Gene idNameDescriptionLocation
BACGene634as-48AS-48 protein70..387
BACGene635as-48BAS-48B protein AS-48 maturation and biosynthesis461..2152
BACGene636as-48CAS-48C protein putative accessory factor in AS-48 secretion2133..2669
BACGene637as-48C1AS-48C1 protein putative ABC transporter3041..3535
BACGene638as-48DAS-48D protein putative ABC transporter3535..4194
BACGene639as-48D1AS-48D1 protein as-48 immunity gene4181..4351
BACGene640as-48D1hypothetical protein ORF64556..5065
BACGene641as-48D1hypothetical protein ORF75043..6266
as-48as-48Bas-48Cas-48C1as-48Das-48D1as-48D1as-48D1
Protein sequence
 ........10 ........20 ........30 ........40 ........50 ........60 ........70 ........80 
          |          |          |          |          |          |          |          | 
 MAKEFGIPAA VAGTVLNVVE AGGWVTTIVS ILTAVGSGGL SLLAAAGRES IKAYLKKEIK KKGKRAVIAW

Wheel representation
wheel representation of Enterocin AS-48 (BACTERIOCIN AS-48)
3D Structure
Protein sequence annotations
Features of Enterocin AS-48 (BACTERIOCIN AS-48)


FeaturePosition(s)LengthDescription
CHAIN1↔7070
peptide antibiotic AS-48.
Feature identifier = PRO_5000146287.
Composition
Hydrophobicity

Composition
Formula C328 H549 N87 O89 S1
Absent amino acids CDHQ
Common amino acids A
Mass (Da) 7186.77
Net charge +6
Isoelectric point 10.83
Basic residues 10
Acidic residues 4
Hydrophobic residues 35
Polar residues 19
Aliphatic residues 20
Tiny residues 25
Boman Index -0.61
Hydropathy Index 0.54
Aliphatic Index 117.14
Instability Index 18.82 (stable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 12490 M-1 cm-1
Absorbance 280nm 181.01

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