Bacteriocin: helveticin-J

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Bacteriocin: helveticin-J

Accession: BAC134

Classification
Class: Unclassified
Genetics
Gene: hlv
Producer and target organisms

Producer Organism: Lactobacillus helveticus [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesLactobacillaceaeLactobacillus

Target organismsUnavailable data

Description
heat-sensitive bacteriocin.
Uniprot and PDB links

UniProt Entry: P22294

PDB EntryUnknown

NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=481.
MEDLINE=91035244;PubMed=2228964;
Joerger M.C., Klaenhammer T.R.
"Cloning, expression, and nucleotide sequence of the Lactobacillus helveticus 481 gene encoding the bacteriocin helveticin J.", J. Bacteriol. 172:6339-6347(1990).
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Gene structure
genome of helveticin-J

Gene idNameDescriptionLocation
BACGene599ORF11..484
BACGene600helveticinORF21638..1952
BACGene601helveticinhelveticin1983..2984
BACGene602helveticinORF43297..3364
helveticinhelveticinhelveticin
Protein sequence
 ........10 ........20 ........30 ........40 ........50 ........60 ........70 ........80 
          |          |          |          |          |          |          |          | 
 MKHLNETTNV RILSQFDMDT GYQAVVQKGN VGSKYVYGLQ LRKGATTILR GYRGSKINNP ILELSGQAGG HTQTWEFAGD
 RKDINGEERA GQWFIGVKPS KIEGSKIIWA KQIARVDLRN QMGPHYSNTD FPRLSYLNRA GSNPFAGNKM THAEAAVSPD
 YTKFLIATVE NNCIGHFTIY NLDTINEKLD EKGNSEDVNL ETVKYEDSFI IDNLYGDDNN SIVNSIQGYD LDNDGNIYIS
 SQKAPDFDGS YYAHH

Protein sequence annotations

FeaturePosition(s)LengthDescription
CHAIN1↔333333
Bacteriocin helveticin-J.
Feature identifier = PRO_0000110580.
Composition
Hydrophobicity

Composition
Formula C1660 H2550 N460 O523 S6
Absent amino acids
Common amino acids GNISK
Mass (Da) 37535.28
Net charge +2
Isoelectric point 6.01
Basic residues 45
Acidic residues 43
Hydrophobic residues 98
Polar residues 120
Aliphatic residues 48
Tiny residues 56
Boman Index -668.44
Hydropathy Index -0.66
Aliphatic Index 75.86
Instability Index 27.38 (stable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 55810 M-1 cm-1
Absorbance 280nm 168.48

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