Bacteriocin: Pyocin S2
Accession: BAC127
Classification
Genetics
Gene: PYS1
Producer and target organisms
Producer Organism: Pseudomonas aeruginosa [Gram-negative]
Taxonomy: Bacteria
ProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Target organismsUnavailable data
Description
Causes breakdown of chromosomal DNA as well as complete inhibition of lipid synthesis in sensitive cells.
Uniprot and PDB links
UniProt Entry: Q06584
PDB EntryUnknown
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-12 AND 483-503, STRAIN=NIH-H;
MEDLINE=93259934;PubMed=8491711;
Sano Y., Matsui H., Kobayashi M., Kageyama M.
"Molecular structures and functions of pyocins S1 and S2 in Pseudomonas aeruginosa.", (1993) J. Bacteriol. 175:2907-2916
MEDLINE=93259934;PubMed=8491711;
Sano Y., Matsui H., Kobayashi M., Kageyama M.
"Molecular structures and functions of pyocins S1 and S2 in Pseudomonas aeruginosa.", (1993) J. Bacteriol. 175:2907-2916
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
MEDLINE=20437337;PubMed=10984043;DOI=10.1038/35023079
Stover, C.K., Pham, X.-Q.T., Erwin, A.L., Mizoguchi, S.D., Warrener, P., Hickey, M.J., Brinkman, F.S.L., Hufnagle, W.O., Kowalik, D.J., Lagrou, M., Garber, R.L., Goltry, L., Tolentino, E., Westbrock-Wadman, S., Yuan, Y., Brody, L.L., Coulter, S.N., Folger, K.R., Kas, A., La
"",
MEDLINE=20437337;PubMed=10984043;DOI=10.1038/35023079
Stover, C.K., Pham, X.-Q.T., Erwin, A.L., Mizoguchi, S.D., Warrener, P., Hickey, M.J., Brinkman, F.S.L., Hufnagle, W.O., Kowalik, D.J., Lagrou, M., Garber, R.L., Goltry, L., Tolentino, E., Westbrock-Wadman, S., Yuan, Y., Brody, L.L., Coulter, S.N., Folger, K.R., Kas, A., La
"",
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Protein sequence
| ........10 ........20 ........30 ........40 ........50 ........60 ........70 ........80 | | | | | | | | AVNDYEPGSM VITHVQGGGR DIIQYIPARS SYGTPPFVPP GPSPYVGTGM QEYRKLRSTL DKSHSELKKN LKNETLKEVD ELKSEAGLPG KAVSANDIRD EKSIVDALMD AKAKSLKAIE DRPANLYTAS DFPQKSESMY QSQLLASRKF YGEFLDRHMS ELAKAYSADI YKAQIAILKQ TSQELENKAR SLEAEAQRAA AEVEADYKAR KANVEKKVQS ELDQAGNALP QLTNPTPEQW LERATQLVTQ AIANK |
Protein sequence annotations
| Feature | Position(s) | Length | Description |
| CHAIN | 1↔688 | 688 | Pyocin-S2. Feature identifier = PRO_0000218686. |
| METAL | 655 | Zinc (By similarity). | |
| METAL | 680 | Zinc (By similarity). | |
| METAL | 684 | Zinc (By similarity). | |
| CONFLICT | 604 | R -> RR (in Ref. 1; AA sequence). |
Composition
Hydrophobicity
Composition
| Formula | C3251
H5233
N919
O1007
S13 |
| Absent amino acids | C |
| Common amino acids | A |
| Mass (Da) | 73752.39 |
| Net charge | +15 |
| Isoelectric point | 6.82 |
| Basic residues | 87 |
| Acidic residues | 72 |
| Hydrophobic residues | 245 |
| Polar residues | 189 |
| Aliphatic residues | 45 |
| Tiny residues | 64 |
| Boman Index | -1089.87 |
| Hydropathy Index | -0.36 |
| Aliphatic Index | 82.65 |
| Instability Index | 38.52 (stable) |
| Half Life |
Mammalian : 4.4 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 65780 M-1 cm-1 |
| Absorbance 280nm | 95.75 |
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