Bacteriocin: Pyocin S2

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Bacteriocin: Pyocin S2

Accession: BAC127

Classification
Genetics
Gene: PYS1
Producer and target organisms
Description
Causes breakdown of chromosomal DNA as well as complete inhibition of lipid synthesis in sensitive cells.
Uniprot and PDB links

UniProt Entry: Q06584

PDB EntryUnknown

NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-12 AND 483-503, STRAIN=NIH-H;
MEDLINE=93259934;PubMed=8491711;
Sano Y., Matsui H., Kobayashi M., Kageyama M.
"Molecular structures and functions of pyocins S1 and S2 in Pseudomonas aeruginosa.", (1993) J. Bacteriol. 175:2907-2916
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
MEDLINE=20437337;PubMed=10984043;DOI=10.1038/35023079
Stover, C.K., Pham, X.-Q.T., Erwin, A.L., Mizoguchi, S.D., Warrener, P., Hickey, M.J., Brinkman, F.S.L., Hufnagle, W.O., Kowalik, D.J., Lagrou, M., Garber, R.L., Goltry, L., Tolentino, E., Westbrock-Wadman, S., Yuan, Y., Brody, L.L., Coulter, S.N., Folger, K.R., Kas, A., La
"",
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Protein sequence
 ........10 ........20 ........30 ........40 ........50 ........60 ........70 ........80 
          |          |          |          |          |          |          |          | 
 AVNDYEPGSM VITHVQGGGR DIIQYIPARS SYGTPPFVPP GPSPYVGTGM QEYRKLRSTL DKSHSELKKN LKNETLKEVD
 ELKSEAGLPG KAVSANDIRD EKSIVDALMD AKAKSLKAIE DRPANLYTAS DFPQKSESMY QSQLLASRKF YGEFLDRHMS
 ELAKAYSADI YKAQIAILKQ TSQELENKAR SLEAEAQRAA AEVEADYKAR KANVEKKVQS ELDQAGNALP QLTNPTPEQW
 LERATQLVTQ AIANK

Protein sequence annotations

FeaturePosition(s)LengthDescription
CHAIN1↔688688
Pyocin-S2.
Feature identifier = PRO_0000218686.
METAL655Zinc (By similarity).
METAL680Zinc (By similarity).
METAL684Zinc (By similarity).
CONFLICT604R -> RR (in Ref. 1; AA sequence).
Composition
Hydrophobicity

Composition
Formula C3251 H5233 N919 O1007 S13
Absent amino acids C
Common amino acids A
Mass (Da) 73752.39
Net charge +15
Isoelectric point 6.82
Basic residues 87
Acidic residues 72
Hydrophobic residues 245
Polar residues 189
Aliphatic residues 45
Tiny residues 64
Boman Index -1089.87
Hydropathy Index -0.36
Aliphatic Index 82.65
Instability Index 38.52 (stable)
Half Life Mammalian : 4.4 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 65780 M-1 cm-1
Absorbance 280nm 95.75

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