Bacteriocin: Pyocin S2
Accession: BAC127
Classification
Genetics
Gene: PYS1
Producer and target organisms
Producer Organism: Pseudomonas aeruginosa [Gram-negative]
Taxonomy: BacteriaProteobacteria
Gammaproteobacteria
Pseudomonadales
Pseudomonadaceae
Pseudomonas
Target organismsUnavailable data
Description
Causes breakdown of chromosomal DNA as well as complete inhibition of lipid synthesis in sensitive cells.
Uniprot and PDB links
UniProt Entry: Q06584
PDB EntryUnknown
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-12 AND 483-503, STRAIN=NIH-H;
MEDLINE=93259934;PubMed=8491711;
Sano Y., Matsui H., Kobayashi M., Kageyama M.
"Molecular structures and functions of pyocins S1 and S2 in Pseudomonas aeruginosa.", (1993) J. Bacteriol. 175:2907-2916
MEDLINE=93259934;PubMed=8491711;
Sano Y., Matsui H., Kobayashi M., Kageyama M.
"Molecular structures and functions of pyocins S1 and S2 in Pseudomonas aeruginosa.", (1993) J. Bacteriol. 175:2907-2916
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
MEDLINE=20437337;PubMed=10984043;DOI=10.1038/35023079
Stover, C.K., Pham, X.-Q.T., Erwin, A.L., Mizoguchi, S.D., Warrener, P., Hickey, M.J., Brinkman, F.S.L., Hufnagle, W.O., Kowalik, D.J., Lagrou, M., Garber, R.L., Goltry, L., Tolentino, E., Westbrock-Wadman, S., Yuan, Y., Brody, L.L., Coulter, S.N., Folger, K.R., Kas, A., La
"",
MEDLINE=20437337;PubMed=10984043;DOI=10.1038/35023079
Stover, C.K., Pham, X.-Q.T., Erwin, A.L., Mizoguchi, S.D., Warrener, P., Hickey, M.J., Brinkman, F.S.L., Hufnagle, W.O., Kowalik, D.J., Lagrou, M., Garber, R.L., Goltry, L., Tolentino, E., Westbrock-Wadman, S., Yuan, Y., Brody, L.L., Coulter, S.N., Folger, K.R., Kas, A., La
"",
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Protein sequence
........10 ........20 ........30 ........40 ........50 ........60 ........70 ........80 | | | | | | | | AVNDYEPGSM VITHVQGGGR DIIQYIPARS SYGTPPFVPP GPSPYVGTGM QEYRKLRSTL DKSHSELKKN LKNETLKEVD ELKSEAGLPG KAVSANDIRD EKSIVDALMD AKAKSLKAIE DRPANLYTAS DFPQKSESMY QSQLLASRKF YGEFLDRHMS ELAKAYSADI YKAQIAILKQ TSQELENKAR SLEAEAQRAA AEVEADYKAR KANVEKKVQS ELDQAGNALP QLTNPTPEQW LERATQLVTQ AIANK |
Protein sequence annotations
Feature | Position(s) | Length | Description |
CHAIN | 1↔688 | 688 | Pyocin-S2. Feature identifier = PRO_0000218686. |
METAL | 655 | Zinc (By similarity). | |
METAL | 680 | Zinc (By similarity). | |
METAL | 684 | Zinc (By similarity). | |
CONFLICT | 604 | R -> RR (in Ref. 1; AA sequence). |
Composition
Hydrophobicity
Composition
Formula | C3251
H5233
N919
O1007
S13 |
Absent amino acids | C |
Common amino acids | A |
Mass (Da) | 73752.39 |
Net charge | +15 |
Isoelectric point | 6.82 |
Basic residues | 87 |
Acidic residues | 72 |
Hydrophobic residues | 245 |
Polar residues | 189 |
Aliphatic residues | 45 |
Tiny residues | 64 |
Boman Index | -1089.87 |
Hydropathy Index | -0.36 |
Aliphatic Index | 82.65 |
Instability Index | 38.52 (stable) |
Half Life |
Mammalian : 4.4 hour Yeast : >20 hour E. coli : >10 hour |
Extinction Coefficient | 65780 M-1 cm-1 |
Absorbance 280nm | 95.75 |
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