Bacteriocin: cytolysin
Accession: BAC113
Classification
Class: Lantibiotic
Genetics
Gene: OrderedLocusNames=BH0453
Producer and target organisms
Producer Organism: Bacillus halodurans [Gram-positive]
Taxonomy: Bacteria
FirmicutesBacillalesBacillaceaeBacillus
Target organismsEnterococcus faecalis - Lactococcus lactis - Lactobacillus leichmanni - Lactobacillus fermenticum - Lactobacillus helveticus - Lactobacillus sakei - Leuconostoc oenos - Streptococcus dysgalactiae
Uniprot and PDB links
UniProt Entry: Q9KFM6
PDB EntryUnknown
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], STRAIN=C-125 / JCM 9153
MEDLINE=20512582;PubMed=11058132;DOI=10.1093/nar/28.21.4317
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis.", Nucleic Acids Res. 28:4317-4331(2000).
MEDLINE=20512582;PubMed=11058132;DOI=10.1093/nar/28.21.4317
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis.", Nucleic Acids Res. 28:4317-4331(2000).
[Ref. 2]
PubMed=17085596;
McClerren AL, Cooper LE, Quan C, Thomas PM, Kelleher NL, van der Donk WA.
"Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic.", Proc Natl Acad Sci U S A. 2006, 103(46):17243-8.
McClerren AL, Cooper LE, Quan C, Thomas PM, Kelleher NL, van der Donk WA.
"Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic.", Proc Natl Acad Sci U S A. 2006, 103(46):17243-8.
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Gene structure
| Gene id | Name | Description | Location |
| BACGene528 | BH0453 | lantibiotic cytolysin precursor BH0453 | complement(482191..482388) |
Protein sequence
| ........10 ........20 ........30 ........40 | | | | GDVHAQTTWP CATVGVSVAL CPTTKCTSQC |
Wheel representation
Composition
Hydrophobicity
Composition
| Formula | C128
H206
N36
O43
S4 |
| Absent amino acids | EFIMNRY |
| Common amino acids | T |
| Mass (Da) | 3084.01 |
| Net charge | +1 |
| Isoelectric point | 7.12 |
| Basic residues | 2 |
| Acidic residues | 1 |
| Hydrophobic residues | 9 |
| Polar residues | 14 |
| Aliphatic residues | 5 |
| Tiny residues | 7 |
| Boman Index | -16.39 |
| Hydropathy Index | 0.257 |
| Aliphatic Index | 10.49 |
| Instability Index | 20.51 (stable) |
| Half Life |
Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 5750 M-1 cm-1 |
| Absorbance 280nm | 198.28 |
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