Bacteriocin: acidocin B (AcdB)

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Bacteriocin: acidocin B (AcdB)

Accession: BAC111

Classification

Class: ~~Unclassified~~

Genetics

Gene: acdB

Producer and target organisms

Producer Organism: Lactobacillus acidophilus [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesLactobacillaceaeLactobacillus

Target organismsListeria monocytogenes - Clostridium sporogenes - Brochothrix thermosphacta - Lactobacillus fermentum - Lactobacillus delbrueckii subsp. bulgaricus -

NOTE: inactive against most other Lactobacillus species.

Uniprot and PDB links

UniProt Entry: Q48498

PDB Entry2MWR resolved by NMR

[Ref. 1] | View abstract | Export citation

NUCLEOTIDE SEQUENCE, STRAIN=M46
MEDLINE=96004462;PubMed=7551031;
Leer R., van der Vossen J., van Giezen M., van Noort H., Pouwels P.
"Genetic analysis of acidocin B, a novel bacteriocin produced by Lactobacillus acidophilus.", Microbiol. 141:1629-1635(1995).

Gene structure

Gene id	Name	Description	Location
BACGene520			858..1040
BACGene521	acdB	acidocin B bacteriocin	1147..1422
BACGene522	acdB		1506..1850

Protein sequence

........10 ........20 ........30 ........40 ........50 ........60
| | | | | |
NIYWIADQFG IHLATGTARK LLDAVASGAS LGTAFAAILG VTLPAWALAA AGALGATAA

Wheel representation

3D Structure

Composition

Hydrophobicity

Composition

Formula	C₂₆₅ H₄₁₇ N₆₉ O₇₄
Absent amino acids	CEM
Common amino acids	A
Mass (Da)	5772.73
Net charge	+1
Isoelectric point	7.54
Basic residues	3
Acidic residues	2
Hydrophobic residues	36
Polar residues	16
Aliphatic residues	14
Tiny residues	27
Boman Index	42.36
Hydropathy Index	0.96
Aliphatic Index	119.66
Instability Index	9.19 (stable)
Half Life	Mammalian : 1.4 hour Yeast : 3 min E. coli : >10 hour
Extinction Coefficient	12490 M^-1 cm^-1
Absorbance 280nm	215.34

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