Bacteriocin: Microcin H47

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Bacteriocin: Microcin H47

Accession: BAC110

Classification
Class: Unclassified
Genetics
Gene: mchB
Producer and target organisms

Producer Organism: Escherichia coli [Gram-negative]

Taxonomy: BacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Target organismsActive on bacteria phylogenetically related to the producing strain.

Description
Mode of action:
Bactericidal antibiotic. ABC transporter system.
Uniprot and PDB links

UniProt Entry: P62530 Q9RM53

PDB EntryUnknown

NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=H47
MEDLINE=99402674;PubMed=10471561;
Rodriguez E., Gaggero C., Lavina M.
"The structural gene for microcin H47 encodes a peptide precursor with antibiotic activity.", Antimicrob. Agents Chemother. 43:2176-2182(1999).
CHARACTERIZATION, STRAIN=H47
MEDLINE=21091907;PubMed=11181394;DOI=10.1128/AAC.45.3.969-972.2001
Azpiroz M.F., Rodriguez E., Lavina M.
"The structure, function, and origin of the microcin H47 ATP-binding cassette exporter indicate its relatedness to that of colicin V.", Antimicrob. Agents Chemother. 45:969-972(2001).
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Gene structure
genome of Microcin H47

Gene idNameDescriptionLocation
BACGene505mchAMchA protein participates in microcin H47 synthesis, IroB homologue, glucosyltransferase1763..2881
BACGene506mchS1MchS1 protein IroD homologue, enterobactin and salmochelin esterasecomplement(3030..4295)
BACGene507mchS2MchS2 protein Microcin I47 precursorcomplement(4593..4826)
BACGene508mchS3MchS3 protein Microcin I47 immunity proteincomplement(4843..5277)
BACGene509mchS4MchS4 protein promotes enterobactin productioncomplement(5432..5677)
BACGene510mchXMchX protein possibly involved in a regulatory loop modulating its own expression and that ofmchI and mchB5901..6020
BACGene511mchIMchI protein Microcin H47 immunity protein6089..6298
BACGene512mchBMchB protein Microcin H47 precursor6315..6542
BACGene513mchCMchC protein participates in Microcin H47 synthesis6813..8363
BACGene514mchDMchD protein participates in Microcin H47 synthesis8389..8841
BACGene515mchEMchE protein membrane-fusion protein, second component of Microcin H47 ABC exporter8994..10268
BACGene516mchFMchF protein ABC protein of Microcin H47 exporter10261..12357
BACGene517mcmI (truncated)McmI (Microcin M immunity protein) truncated protein12393..12539
BACGene518mcmA (truncated)McmA (Microcin M precursor) truncated protein12610..12831
BACGene519mcmM (truncated)McmM (Microcin M-related protein) truncated proteincomplement(13347..13637)
mchAmchS1mchS2mchS3mchS4mchXmchImchBmchCmchDmchEmchFmcmI (truncated)mcmA (truncated)mcmM (truncated)
Protein sequence
 ........10 ........20 ........30 ........40 ........50 ........60 ........70 
          |          |          |          |          |          |          | 
 GGAPATSANA AGAAAIVGAL AGIPGGPLGV VVGAVSAGLT TAIGSTVGSG SASSSAGGGS

Wheel representation
wheel representation of Microcin H47
Protein sequence annotations
Features of Microcin H47


FeaturePosition(s)LengthDescription
CHAIN1↔6060
Microcin H47.
Feature identifier = PRO_0000021661.
HELIX15↔3521Potential.
Composition
Hydrophobicity

Composition
Formula C205 H345 N61 O75
Absent amino acids CDEFHKMQRWY
Common amino acids GA
Mass (Da) 4883.4
Net charge 0
Isoelectric point 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 27
Polar residues 30
Aliphatic residues 12
Tiny residues 40
Boman Index 48.43
Hydropathy Index 0.87
Aliphatic Index 93
Instability Index 17.69 (stable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 0 M-1 cm-1
Absorbance 280nm 0

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