Bacteriocin: lactococcin-A
Accession: BAC102
Classification
Class: Unclassified
Genetics
Gene: lcnA
Producer and target organisms
Producer Organism: Lactococcus lactis subsp (Streptococcus cremoris), cremoris [Gram-positive]
Taxonomy: BacteriaFirmicutes
Lactobacillales
Streptococcaceae
Lactococcus
Target organismsLactococci
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=9B4; PLASMID=p9B4-6
MEDLINE=91197113;PubMed=1901707;
van Belkum M.J., Hayema B.J., Jeeninga R.E., Kok J., Venema G.
"Organization and nucleotide sequences of two lactococcal bacteriocin operons.", Appl. Environ. Microbiol. 57:492-498(1991).
MEDLINE=91197113;PubMed=1901707;
van Belkum M.J., Hayema B.J., Jeeninga R.E., Kok J., Venema G.
"Organization and nucleotide sequences of two lactococcal bacteriocin operons.", Appl. Environ. Microbiol. 57:492-498(1991).
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 22-75, STRAIN=LMG 2130
MEDLINE=91267955;PubMed=1904860;
Holo H., Nilssen O., Nes I.F.
"Lactococcin A, a new bacteriocin from Lactococcus lactis subsp. cremoris: isolation and characterization of the protein and its gene.", J. Bacteriol. 173:3879-3887(1991).
MEDLINE=91267955;PubMed=1904860;
Holo H., Nilssen O., Nes I.F.
"Lactococcin A, a new bacteriocin from Lactococcus lactis subsp. cremoris: isolation and characterization of the protein and its gene.", J. Bacteriol. 173:3879-3887(1991).
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Gene structure
Gene id | Name | Description | Location |
BACGene442 | probacteriocin | 239..466 | |
BACGene443 | bacteriocin immunity | 481..777 |
Protein sequence
........10 ........20 ........30 ........40 ........50 ........60 | | | | | | KLTFIQSTAA GDLYYNTNTH KYVYQQTQNA FGAAANTIVN GWMGGAAGGF GLHH |
Wheel representation
Protein sequence annotations
Feature | Position(s) | Length | Description |
CHAIN | 1↔54 | 54 | Bacteriocin lactococcin-A. Feature identifier = PRO_0000002769.
|
HELIX | 9↔31 | 23 | Potential |
Composition
Hydrophobicity
Composition
Formula | C260
H380
N72
O77
S1 |
Absent amino acids | CEPR |
Common amino acids | AG |
Mass (Da) | 5797.31 |
Net charge | +4 |
Isoelectric point | 8.97 |
Basic residues | 5 |
Acidic residues | 1 |
Hydrophobic residues | 19 |
Polar residues | 24 |
Aliphatic residues | 7 |
Tiny residues | 17 |
Boman Index | -40.24 |
Hydropathy Index | -0.24 |
Aliphatic Index | 61.67 |
Instability Index | 22.35 (stable) |
Half Life |
Mammalian : 1.3 hour Yeast : 3 min E. coli : 2 min |
Extinction Coefficient | 11460 M-1 cm-1 |
Absorbance 280nm | 216.23 |
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