Bacteriocin: salivaricin A
Accession: BAC099
Classification
Class: Lantibiotic
Genetics
Gene: salA; OrderedLocusNames=M28_Spy1621
Producer and target organisms
Producer Organism: Streptococcus pyogenes serotype M28 [Gram-positive]
Taxonomy: BacteriaFirmicutes
Lactobacillales
Streptococcaceae
Streptococcus
Target organismsUnavailable data
Description
Annotated by homology to Salivaricin A (BAC016).
Uniprot and PDB links
UniProt Entry: Q48RC9
PDB EntryUnknown
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], STRAIN=MGAS6180 / Serotype M28
PubMed=16088825;DOI=10.1086/430618
Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B., Lefebvre R.B., Musser J.M.
"Genome sequence of a serotype M28 strain of group A Streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity.", J. Infect. Dis. 192:760-770(2005).
PubMed=16088825;DOI=10.1086/430618
Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B., Lefebvre R.B., Musser J.M.
"Genome sequence of a serotype M28 strain of group A Streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity.", J. Infect. Dis. 192:760-770(2005).
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Gene structure
Gene id | Name | Description | Location |
BACGene417 | salA | lantibiotic salivaricin A | complement(1625261..1625416) |
Protein sequence
........10 ........20 ........30 | | | KKGSGWFATI TDDCPNSVFV CC |
Wheel representation
Composition
Hydrophobicity
Composition
Formula | C104
H156
N26
O32
S3 |
Absent amino acids | EHLMQRY |
Common amino acids | C |
Mass (Da) | 2387.08 |
Net charge | 0 |
Isoelectric point | 6.11 |
Basic residues | 2 |
Acidic residues | 2 |
Hydrophobic residues | 7 |
Polar residues | 10 |
Aliphatic residues | 3 |
Tiny residues | 5 |
Boman Index | -18.3 |
Hydropathy Index | -0.15 |
Aliphatic Index | 48.64 |
Instability Index | 20.05 (stable) |
Half Life |
Mammalian : 1.3 hour Yeast : 3 min E. coli : 2 min |
Extinction Coefficient | 5500 M-1 cm-1 |
Absorbance 280nm | 267.86 |
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