Bacteriocin: subtilosin

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Bacteriocin: subtilosin

Accession: BAC098

Classification
Class: Unclassified
Genetics
Gene: sboX; OrderedLocusNames=BSU37360
Uniprot and PDB links

UniProt Entry: Q7WY57

PDB EntryUnknown

IDENTIFICATION, AND INDUCTION, STRAIN=168 / JH642
MEDLINE=20270159;PubMed=10809709;DOI=10.1128/JB.182.11.3266-3273.2000
Zheng G., Hehn R., Zuber P.
"Mutational analysis of the sbo-alb locus of Bacillus subtilis: identification of genes required for subtilosin production and immunity.", J. Bacteriol. 182:3266-3273(2000).
FUNCTION
PubMed=17213266;
Shelburne CE, An FY, Dholpe V, Ramamoorthy A, Lopatin DE, Lantz MS.
"The spectrum of antimicrobial activity of the bacteriocin subtilosin A.", J Antimicrob Chemother. 2007 Feb;59(2):297-300.
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Reference Manager
BibTeX
Gene structure
genome of subtilosin

Gene idNameDescriptionLocation
BACGene409sboAsubtilosin A 16.4: Excrete 16.5: Explore 16.8: Protect Evidence 1a: Function experimentally demonstrated in the studied strain;PubMedId: 12696888, 15743949, 16095584, 17213266; Product type f: factor3836058..3836189
BACGene410albAputative antilisterial bacteriocin (subtilosin) production enzyme 16.5: Explore Evidence 3: Function proposed based on presence of conserved amino acid motif,structural feature or limited homology; PubMedId: 15066831, 15743949; Producttype pe3836323..3837669
BACGene411albBputative membrane component involved in subtilosin production 16.4: Excrete 16.5: Explore Evidence 3: Function proposed based on presence of conserved amino acid motif,structural feature or limited homology; PubMedId: 10809709, 15743949;3837682..3837843
BACGene412albCputative transporter involved in subtilosin production 16.4: Excrete 16.5: Explore 16.6: Maintain Evidence 3: Function proposed based on presence of conserved amino acid motif,structural feature or limited homology; PubMedId: 10809703837840..3838559
BACGene413albDputative integral inner membrane protein involved in subtilosin production andimmunity Evidence 3: Function proposed based on presence of conserved amino acid motif,structural feature or limited homology; PubMedId: 10809709, 15066831, 15743949,153838552..3839862
BACGene414albEputative hydrolase involved in subtilosin production 16.4: Excrete 16.8: Protect 16.5: Explore Evidence 3: Function proposed based on presence of conserved amino acid motif,structural feature or limited homology; PubMedId: 10809709,3839852..3841012
BACGene415albFputative peptidase involved in subtilosin production 16.4: Excrete 16.5: Explore 16.8: Protect Evidence 3: Function proposed based on presence of conserved amino acid motif,structural feature or limited homology; PubMedId: 10809709,3841017..3842297
BACGene416albGputative integral inner membrane protein involved in subtilosin production andimmunity Evidence 3: Function proposed based on presence of conserved amino acid motif,structural feature or limited homology; PubMedId: 10809709, 15066831, 15849754,163842294..3842995
sboAalbAalbBalbCalbDalbEalbFalbG
Protein sequence
 ........10 ........20 ........30 ........40 ........50 ........60 
          |          |          |          |          |          | 
 MKLPVQQVYS VYGGKDLPKG HSHSTMPFLS KLQFLTKIYL LDIHTQPFFI

Wheel representation
wheel representation of subtilosin
Protein sequence annotations
Features of subtilosin


FeaturePosition(s)LengthDescription
CHAIN1↔5050
Bacteriocin-like protein SboX.
Feature identifier = PRO_0000097605.
Composition
Hydrophobicity

Composition
Formula C274 H421 N65 O69 S2
Absent amino acids ACENRW
Common amino acids L
Mass (Da) 5812.7
Net charge +6
Isoelectric point 10.01
Basic residues 8
Acidic residues 2
Hydrophobic residues 17
Polar residues 13
Aliphatic residues 13
Tiny residues 7
Boman Index -22.3
Hydropathy Index 0.02
Aliphatic Index 95.4
Instability Index 37.77 (stable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 4470 M-1 cm-1
Absorbance 280nm 91.22

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