Bacteriocin: subtilosin
Accession: BAC098
Classification
Class: Unclassified
Genetics
Gene: sboX; OrderedLocusNames=BSU37360
Producer and target organisms
Producer Organism: Bacillus subtilis [Gram-positive]
Taxonomy: Bacteria
FirmicutesBacillalesBacillaceaeBacillus
Target organismsBacillus subtilis - Enterococcus faecalis - Escherichia coli - Fusobacterium nucleatum - Listeria monocytogenes - Porphyromonas gingivalis - Pseudomonas aeruginosa - Staphylococcus aureus - Klebsiella pneumoniae - Bacillus cereus - Staphylococcus epidermidis - Kocuria rhizophila - Enterobacter aerogenes - Proteus mirabilis - Salmonella enterica Typhi - Streptococcus pyogenes - Streptococcus gordonii Challis - Shigella sonnei
Uniprot and PDB links
UniProt Entry: Q7WY57
PDB EntryUnknown
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], STRAIN=168
MEDLINE=98044033;PubMed=9384377;DOI=10.1038/36786
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter
"?",
MEDLINE=98044033;PubMed=9384377;DOI=10.1038/36786
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter
"?",
IDENTIFICATION, AND INDUCTION, STRAIN=168 / JH642
MEDLINE=20270159;PubMed=10809709;DOI=10.1128/JB.182.11.3266-3273.2000
Zheng G., Hehn R., Zuber P.
"Mutational analysis of the sbo-alb locus of Bacillus subtilis: identification of genes required for subtilosin production and immunity.", J. Bacteriol. 182:3266-3273(2000).
MEDLINE=20270159;PubMed=10809709;DOI=10.1128/JB.182.11.3266-3273.2000
Zheng G., Hehn R., Zuber P.
"Mutational analysis of the sbo-alb locus of Bacillus subtilis: identification of genes required for subtilosin production and immunity.", J. Bacteriol. 182:3266-3273(2000).
FUNCTION
PubMed=17213266;
Shelburne CE, An FY, Dholpe V, Ramamoorthy A, Lopatin DE, Lantz MS.
"The spectrum of antimicrobial activity of the bacteriocin subtilosin A.", J Antimicrob Chemother. 2007 Feb;59(2):297-300.
PubMed=17213266;
Shelburne CE, An FY, Dholpe V, Ramamoorthy A, Lopatin DE, Lantz MS.
"The spectrum of antimicrobial activity of the bacteriocin subtilosin A.", J Antimicrob Chemother. 2007 Feb;59(2):297-300.
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Gene structure
| Gene id | Name | Description | Location |
| BACGene409 | sboA | subtilosin A 16.4: Excrete 16.5: Explore 16.8: Protect Evidence 1a: Function experimentally demonstrated in the studied strain;PubMedId: 12696888, 15743949, 16095584, 17213266; Product type f: factor | 3836058..3836189 |
| BACGene410 | albA | putative antilisterial bacteriocin (subtilosin) production enzyme 16.5: Explore Evidence 3: Function proposed based on presence of conserved amino acid motif,structural feature or limited homology; PubMedId: 15066831, 15743949; Producttype pe | 3836323..3837669 |
| BACGene411 | albB | putative membrane component involved in subtilosin production 16.4: Excrete 16.5: Explore Evidence 3: Function proposed based on presence of conserved amino acid motif,structural feature or limited homology; PubMedId: 10809709, 15743949; | 3837682..3837843 |
| BACGene412 | albC | putative transporter involved in subtilosin production 16.4: Excrete 16.5: Explore 16.6: Maintain Evidence 3: Function proposed based on presence of conserved amino acid motif,structural feature or limited homology; PubMedId: 1080970 | 3837840..3838559 |
| BACGene413 | albD | putative integral inner membrane protein involved in subtilosin production andimmunity Evidence 3: Function proposed based on presence of conserved amino acid motif,structural feature or limited homology; PubMedId: 10809709, 15066831, 15743949,15 | 3838552..3839862 |
| BACGene414 | albE | putative hydrolase involved in subtilosin production 16.4: Excrete 16.8: Protect 16.5: Explore Evidence 3: Function proposed based on presence of conserved amino acid motif,structural feature or limited homology; PubMedId: 10809709, | 3839852..3841012 |
| BACGene415 | albF | putative peptidase involved in subtilosin production 16.4: Excrete 16.5: Explore 16.8: Protect Evidence 3: Function proposed based on presence of conserved amino acid motif,structural feature or limited homology; PubMedId: 10809709, | 3841017..3842297 |
| BACGene416 | albG | putative integral inner membrane protein involved in subtilosin production andimmunity Evidence 3: Function proposed based on presence of conserved amino acid motif,structural feature or limited homology; PubMedId: 10809709, 15066831, 15849754,16 | 3842294..3842995 |
Protein sequence
| ........10 ........20 ........30 ........40 ........50 ........60 | | | | | | MKLPVQQVYS VYGGKDLPKG HSHSTMPFLS KLQFLTKIYL LDIHTQPFFI |
Wheel representation
Protein sequence annotations
| Feature | Position(s) | Length | Description |
| CHAIN | 1↔50 | 50 | Bacteriocin-like protein SboX. Feature identifier = PRO_0000097605. |
Composition
Hydrophobicity
Composition
| Formula | C274
H421
N65
O69
S2 |
| Absent amino acids | ACENRW |
| Common amino acids | L |
| Mass (Da) | 5812.7 |
| Net charge | +6 |
| Isoelectric point | 10.01 |
| Basic residues | 8 |
| Acidic residues | 2 |
| Hydrophobic residues | 17 |
| Polar residues | 13 |
| Aliphatic residues | 13 |
| Tiny residues | 7 |
| Boman Index | -22.3 |
| Hydropathy Index | 0.02 |
| Aliphatic Index | 95.4 |
| Instability Index | 37.77 (stable) |
| Half Life |
Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 4470 M-1 cm-1 |
| Absorbance 280nm | 91.22 |
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