Bacteriocin: Salivaricin A3
Accession: BAC094
Classification
Class: Lantibiotic
Genetics
Gene: salA3
Producer and target organisms
Producer Organism: Streptococcus salivarius [Gram-positive]
Taxonomy: Bacteria
FirmicutesLactobacillalesStreptococcaceaeStreptococcus
Target organismsUnavailable data
Description
Mode of action:
Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.
Annotation was done by homology to salivaricin A.
Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.
Annotation was done by homology to salivaricin A.
Uniprot and PDB links
UniProt Entry: Q38L35
PDB EntryUnknown
NUCLEOTIDE SEQUENCE, STRAIN=JH
PubMed=16461700;DOI=10.1128/AEM.72.2.1459-1466.2006
Wescombe P.A., Upton M., Dierksen K.P., Ragland N.L., Sivabalan S., Wirawan R.E., Inglis M.A., Moore C.J., Walker G.V., Chilcott C.N., Jenkinson H.F., Tagg J.R.
"Production of the Lantibiotic Salivaricin A and Its Variants by Oral Streptococci and Use of a Specific Induction Assay To Detect Their Presence in Human Saliva.", Appl. Environ. Microbiol. 72:1459-1466(2006).
PubMed=16461700;DOI=10.1128/AEM.72.2.1459-1466.2006
Wescombe P.A., Upton M., Dierksen K.P., Ragland N.L., Sivabalan S., Wirawan R.E., Inglis M.A., Moore C.J., Walker G.V., Chilcott C.N., Jenkinson H.F., Tagg J.R.
"Production of the Lantibiotic Salivaricin A and Its Variants by Oral Streptococci and Use of a Specific Induction Assay To Detect Their Presence in Human Saliva.", Appl. Environ. Microbiol. 72:1459-1466(2006).
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Gene structure
| Gene id | Name | Description | Location |
| BACGene387 | salA3 | salivaricin A3 precursor lantibiotic | 1..147 |
Protein sequence
| ........10 ........20 ........30 | | | KKGPGWIATI TDDCPNSIFV CC |
Wheel representation
Composition
Hydrophobicity
Composition
| Formula | C104
H162
N26
O31
S3 |
| Absent amino acids | EHLMQRY |
| Common amino acids | CI |
| Mass (Da) | 2387.14 |
| Net charge | 0 |
| Isoelectric point | 6.11 |
| Basic residues | 2 |
| Acidic residues | 2 |
| Hydrophobic residues | 7 |
| Polar residues | 9 |
| Aliphatic residues | 4 |
| Tiny residues | 4 |
| Boman Index | -12.08 |
| Hydropathy Index | 0.2 |
| Aliphatic Index | 70.91 |
| Instability Index | 20.05 (stable) |
| Half Life |
Mammalian : 1.3 hour Yeast : 3 min E. coli : 2 min |
| Extinction Coefficient | 5500 M-1 cm-1 |
| Absorbance 280nm | 267.86 |
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