Bacteriocin: carnobacteriocin B2 (Carnocin CP52)

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Bacteriocin: carnobacteriocin B2 (Carnocin CP52)

Accession: BAC091

Classification
Genetics
Gene: cbnB2; Synonyms=canCP52
Producer and target organisms
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 19-56, STRAIN=LV17B
MEDLINE=94216339;PubMed=8163526;
Quadri L.E.N., Sailer M., Roy K.L., Vederas J.C., Stiles M.E.
"Chemical and genetic characterization of bacteriocins produced by Carnobacterium piscicola LV17B.", J. Biol. Chem. 269:12204-12211(1994).
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=CP5
MEDLINE=98063519;PubMed=9353214;DOI=10.1007/s002849900262
Herbin S., Mathieu F., Brule F., Branlant C., Lefebvre G., Lebrihi A.
"Characteristics and genetic determinants of bacteriocin activities produced by Carnobacterium piscicola CP5 isolated from cheese.", Curr. Microbiol. 35:319-326(1997).
STRUCTURE BY NMR OF 19-66.
MEDLINE=20039867;PubMed=10569926;DOI=10.1021/bi991351x
Wang Y., Henz M.E., Gallagher N.L.F., Chai S., Gibbs A.C., Yan L.Z., Stiles M.E., Wishart D.S., Vederas J.C.
"Solution structure of carnobacteriocin B2 and implications for structure-activity relationships among type IIa bacteriocins from lactic acid bacteria.", Biochemistry 38:15438-15447(1999).
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Gene structure
genome of carnobacteriocin B2 (Carnocin CP52)

Gene idNameDescriptionLocation
BACGene356transposase ORF-1; putative1..564
BACGene357transposase ORF-2; putativecomplement(491..949)
BACGene358ORF-3; unknown functioncomplement(1422..1550)
BACGene359bacteriocin ORF-4; putativecomplement(1776..1922)
BACGene360bacteriocin ORF-5; putativecomplement(1944..2099)
BACGene361bacteriocin ORF-6; putative2324..2449
BACGene362cbnKhistidine protein kinase2492..3820
BACGene363cbnRresponse regulator3795..4532
BACGene364cbnTATP-dependent translocator4558..6708
BACGene365cbnDaccessory protein6724..8091
BACGene366cbnDORF-7; unknown function8849..9178
BACGene367cbnB2carnobacteriocin B29296..9496
BACGene368cbiB2carnobacteriocin B2 immunity protein9533..9868
cbnKcbnRcbnTcbnDcbnDcbnB2cbiB2
Protein sequence
 ........10 ........20 ........30 ........40 ........50 
          |          |          |          |          | 
 VNYGNGVSCS KTKCSVNWGQ AFQERYTAGI NSFVSGVASG AGSIGRRP

Wheel representation
wheel representation of carnobacteriocin B2 (Carnocin CP52)
3D Structure
Protein sequence annotations
Features of carnobacteriocin B2 (Carnocin CP52)


FeaturePosition(s)LengthDescription
CHAIN1↔4848
Bacteriocin carnobacteriocin B2.
Feature identifier = PRO_0000002737.
DISULFID9↔146
STRAND4↔85
STRAND10↔123
HELIX18↔4124
Composition
Hydrophobicity

Composition
Formula C213 H332 N66 O68 S2
Absent amino acids DHLM
Common amino acids G
Mass (Da) 4988.27
Net charge +4
Isoelectric point 9.96
Basic residues 5
Acidic residues 1
Hydrophobic residues 14
Polar residues 25
Aliphatic residues 7
Tiny residues 19
Boman Index -73.88
Hydropathy Index -0.28
Aliphatic Index 54.79
Instability Index 18.67 (stable)
Half Life Mammalian : 100 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 8605 M-1 cm-1
Absorbance 280nm 183.09

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