Bacteriocin: lactococcin-B

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Bacteriocin: lactococcin-B

Accession: BAC087

Classification
Class: Unclassified
Genetics
Gene: lcnB
Producer and target organisms

Producer Organism: Lactococcus lactis subsp (Streptococcus cremoris), cremoris [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesStreptococcaceaeLactococcus

Target organismsLactococci

Description
Mode of action:
Kills Lactococci by dissipating the membrane potential of the cells.
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=9B4
MEDLINE=92304065;PubMed=1610182;
van Belkum M.J., Kok J., Venema G.
"Cloning, sequencing, and expression in Escherichia coli of lcnB, a third bacteriocin determinant from the lactococcal bacteriocin plasmid p9B4-6.", Appl. Environ. Microbiol. 58:572-577(1992).
MUTAGENESIS OF CYS-45.
MEDLINE=97039852;PubMed=8885398;
Venema K., Dost M.H., Venema G., Kok J.
"Mutational analysis and chemical modification of Cys24 of lactococcin B, a bacteriocin produced by Lactococcus lactis.", Microbiology 142:2825-2830(1996).
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Gene structure
genome of lactococcin-B

Gene idNameDescriptionLocation
BACGene316lciAlactococcin A immunity; This sequence comes from Fig. 21..75
BACGene317lcnBbacteriocin lactococcin B This sequence comes from Fig. 2.350..556
BACGene318lciBlactococcin B immunity; This sequence comes from Fig. 2583..858
lciAlcnBlciB
Protein sequence
 ........10 ........20 ........30 ........40 ........50 
          |          |          |          |          | 
 SLQYVMSAGP YTWYKDTRTG KTICKQTIDT ASYTFGVMAE GWGKTFH

Wheel representation
wheel representation of lactococcin-B
Protein sequence annotations
Features of lactococcin-B


FeaturePosition(s)LengthDescription
CHAIN1↔4747
Bacteriocin lactococcin-B.
Feature identifier = PRO_0000002771.
MUTAGEN24C->A,D,E,F,G,I,L,M,N,P,Q,S,T,V,Y,W: Noloss of activity.
MUTAGEN24C->R,K: Loss of activity.
Composition
Hydrophobicity

Composition
Formula C241 H358 N60 O71 S3
Absent amino acids N
Common amino acids T
Mass (Da) 5346.8
Net charge +3
Isoelectric point 9.1
Basic residues 6
Acidic residues 3
Hydrophobic residues 12
Polar residues 21
Aliphatic residues 5
Tiny residues 11
Boman Index -58.86
Hydropathy Index -0.44
Aliphatic Index 43.62
Instability Index 19.18 (stable)
Half Life Mammalian : 1.9 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 16960 M-1 cm-1
Absorbance 280nm 368.7

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