Bacteriocin: pediocin PA-1 (Pediocin ACH)

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Bacteriocin: pediocin PA-1 (Pediocin ACH)

Accession: BAC083

Classification
Genetics
Gene: pedA; Synonyms=pap, papA
Description
Mode of action:
Bactericidal activity (effective inhibitor of Listeria monocytogenes).
Uniprot and PDB links

UniProt Entry: P29430 P34912

PDB Entry5UKZ resolved by NMR

NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=PAC-1.0; PLASMID=pSRQ11
MEDLINE=92384551;PubMed=1514784;
Marugg J.D., Gonzalez C.F., Kunka B.S., Ledeboer A.M., Pucci M.J., Toonen M.Y., Walker S.A., Zoetmulder L.C.M., Vandenbergh P.A.
"Cloning, expression, and nucleotide sequence of genes involved in production of pediocin PA-1, and bacteriocin from Pediococcus acidilactici PAC1.0.", Appl. Environ. Microbiol. 58:2360-2367(1992).
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=H; PLASMID=pSMB74
MEDLINE=94288967;PubMed=7764941;
Motlagh A.M., Bukhtiyarova M.B., Ray B.R.
"Complete nucleotide sequence of pSMB 74, a plasmid encoding the production of pediocin AcH in Pediococcus acidilactici.", Lett. Appl. Microbiol. 18:305-312(1994).
PROTEIN SEQUENCE OF 19-62, AND DISULFIDE BONDS, STRAIN=PAC-1.0; PLASMID=pSRQ11
MEDLINE=92246549;PubMed=1575516;
Henderson J.T., Chopko A.L., van Wassenaar P.D.
"Purification and primary structure of pediocin PA-1 produced by Pediococcus acidilactici PAC-1.0.", Arch. Biochem. Biophys. 295:5-12(1992).
PROTEIN SEQUENCE OF 19-61.
MEDLINE=93019000;PubMed=1402795;
Lozano J.C.N., Meyer J.N., Sletten K., Pelaz C., Nes I.F.
"Purification and amino acid sequence of a bacteriocin produced by Pediococcus acidilactici.", J. Gen. Microbiol. 138:1985-1990(1992).
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Gene structure
genome of pediocin PA-1  (Pediocin ACH)

Gene idNameDescriptionLocation
BACGene297repBRepB Orf319; involved in plasmid replication and maintenance; frequently found intheta-replicating plasmids from lactic acid bacteria800..1759
BACGene298repBreplication protein Orf192; involved in plasmid replication and maintenance; frequently found intheta-replicating plasmids from lactic acid bacteria; OrfX1752..2330
BACGene299papAPapA3271..3459
BACGene300papBPapB3497..3835
BACGene301papCPapC3859..4383
BACGene302papDPapD4482..6656
BACGene303papDPemK-like protein Orf114b; plasmid maintenance system proteincomplement(7247..7591)
BACGene304papDPemI-like protein Orf114a; plasmid maintenance system proteincomplement(7585..7929)
BACGene305papDtyrosine recombinase Orf264; involved in plasmid replication and maintenance; frequently found intheta-replicating plasmids from lactic acid bacteria7727..8521
repBrepBpapApapBpapCpapDpapDpapDpapD
Protein sequence
 ........10 ........20 ........30 ........40 ........50 
          |          |          |          |          | 
 KYYGNGVTCG KHSCSVDWGK ATTCIINNGA MAWATGGHQG NHKC

Wheel representation
wheel representation of pediocin PA-1  (Pediocin ACH)
3D Structure
Protein sequence annotations
Features of pediocin PA-1  (Pediocin ACH)


FeaturePosition(s)LengthDescription
CHAIN1↔4444
Bacteriocin pediocin PA-1.
Feature identifier = PRO_0000002746.
REGION22↔3413Hydrophobic.
DISULFID9↔146
DISULFID24↔4421
Composition
Hydrophobicity

Composition
Formula C196 H297 N61 O60 S5
Absent amino acids EFLPR
Common amino acids G
Mass (Da) 4646.95
Net charge +6
Isoelectric point 8.67
Basic residues 7
Acidic residues 1
Hydrophobic residues 10
Polar residues 24
Aliphatic residues 4
Tiny residues 14
Boman Index -49.55
Hydropathy Index -0.49
Aliphatic Index 40
Instability Index -0.48 (stable)
Half Life Mammalian : 1.3 hour
Yeast : 3 min
E. coli : 2 min
Extinction Coefficient 14230 M-1 cm-1
Absorbance 280nm 330.93

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