Bacteriocin: Enterocin 7A (Enterocin L50A)

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NUCLEOTIDE SEQUENCE, STRAIN=6T1a
MEDLINE=99054929;PubMed=9835578;
Floriano B., Ruiz-Barba J.L., Jimenez-Diaz R.
"Purification and genetic characterization of enterocin I from Enterococcus faecium 6T1a, a novel antilisterial plasmid-encoded bacteriocin which does not belong to the pediocin family of bacteriocins.", Appl. Environ. Microbiol. 64:4883-4890(1998).
NUCLEOTIDE SEQUENCE, STRAIN=L50
MEDLINE=98215162;PubMed=9555877;
Cintas L.M., Casaus P., Holo H., Hernandez P.E., Nes I.F., Havarstein L.S.
"Enterocins L50A and L50B, two novel bacteriocins from Enterococcus faecium L50, are related to staphylococcal hemolysins.", J. Bacteriol. 180:1988-1994(1998).
NUCLEOTIDE SEQUENCE, STRAIN=MRR 10-3.
PubMed=16751538;DOI=10.1128/AEM.02940-05
Martin-Platero A.M., Valdivia E., Ruiz-Rodriguez M., Soler J.J., Martin-Vivaldi M., Maqueda M., Martinez-Bueno M.
"Characterization of antimicrobial substances produced by Enterococcus faecalis MRR 10-3, isolated from the uropygial gland of the hoopoe (Upupa epops).", Appl. Environ. Microbiol. 72:4245-4249(2006).
NUCLEOTIDE SEQUENCE, STRAIN=N1-33.
Hata T., Alemu M., Kobayashi M., Tanaka R., Sato T., Suzuki C., Nitisinprasert S., Ohmomo S.
"Identification of enterocin N produced by Enterococcus faecalis N1-33 isolated from fermented vegetables in Thailand and its application to ready-to-eat foods as a biopreservative.", Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
NUCLEOTIDE SEQUENCE, STRAIN=DBH18.
Jimenez J.J., Borrero J., Sanchez J., Diep D.B., Herranz C., Nes I.F., Cintas L.M., Hernandez P.E.
"Enterococcus faecalis DBH18, isolated from Mallard ducks (Anas platyrhynchos), encodes the bacteriocin-producing genes ef1097, entL50A-entL50B, and the entL50A-entL50B-like genes termed entJSA and entJSB.", Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
3D STRUCTURE
PubMed=23725536;DOI=10.1021/bi400359z
Lohans C.T., Towle K.M., Miskolzie M., McKay R.T., van Belkum M.J., McMullen L.M., Vederas J.C.
"Solution Structures of the Linear Leaderless Bacteriocins Enterocin 7A and 7B Resemble Carnocyclin A, a Circular Antimicrobial Peptide", Biochemistry 52: 3987-3994 (2013).
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Gene structure
genome of Enterocin 7A (Enterocin L50A)

Gene idNameDescriptionLocation
BACGene278hypothetical protein orf11..1830
BACGene279enterocin JSA leader-less enterocin; entJSA2370..2504
BACGene280enterocin JSB leader-less enterocin; entJSB2525..2656
BACGene281hypothetical protein orf42877..3146
BACGene282hypothetical protein orf53147..3416
BACGene283hypothetical protein orf63420..3839
BACGene284hypothetical protein orf73836..5212
BACGene285hypothetical protein orf85222..5713
BACGene286hypothetical protein orf95706..6926
BACGene287hypothetical protein orf106923..7606
BACGene288hypothetical protein orf117603..8802
BACGene289hypothetical protein orf129758..11383
Protein sequence
 ........10 ........20 ........30 ........40 ........50 
          |          |          |          |          | 
 MGAIAKLVAK FGWPIVKKYY KQIMQFIGEG WAINKIIDWI KKHI

Wheel representation
wheel representation of Enterocin 7A (Enterocin L50A)
3D Structure
Protein sequence annotations
Features of Enterocin 7A (Enterocin L50A)


FeaturePosition(s)LengthDescription
PEPTIDE1↔4444
Enterocin 7A.
Feature identifier =
HELIX5↔84
HELIX13↔164
HELIX23↔275
HELIX36↔438
Composition
Hydrophobicity

Composition
Formula C252 H392 N60 O54 S2
Absent amino acids CRST
Common amino acids I
Mass (Da) 5177.18
Net charge +7
Isoelectric point 10.68
Basic residues 9
Acidic residues 2
Hydrophobic residues 21
Polar residues 7
Aliphatic residues 12
Tiny residues 8
Boman Index 3.34
Hydropathy Index 0.202
Aliphatic Index 110.91
Instability Index 20.08 (stable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 19480 M-1 cm-1
Absorbance 280nm 453.02

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