Bacteriocin: Enterocin P

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Bacteriocin: Enterocin P

Accession: BAC079

Classification
Genetics
Gene: entP
Producer and target organisms
Description
Enterococcus faecium L50 produces, in addition to EntL50, the sec-dependent pediocin-like enterocin P (EntP), and an unmodified non-pediocin-like bacteriocin, termed enterocin Q (EntQ), synthesized without an N-terminal leader sequence or signal peptide. Note=Ref2.

Classification note:
Enterocin P classification is problematic since it classified in class IIa, IIb and IIc according to literature. To review its classification, please see Zouhir et al., 2007.
NUCLEOTIDE SEQUENCE, STRAIN=L50
MEDLINE=20528333;PubMed=11073927;DOI=10.1128/JB.182.23.6806-6814.2000
Cintas L.M., Casaus P., Herranz C., Havarstein L.S., Holo H., Hernandez P.E., Nes I.F.
"Biochemical and genetic evidence that Enterococcus faecium L50 produces enterocins L50A and L50B, the sec-dependent enterocin P, and a novel bacteriocin secreted without an N-terminal extension termed enterocin Q.", J. Bacteriol. 182:6806-6814(2000).
NUCLEOTIDE SEQUENCE, STRAIN=P13
MEDLINE=98027370;PubMed=9361419;
Cintas L.M., Casaus P., Havarstein L.S., Hernandez P.E., Nes I.F.
"Biochemical and genetic characterization of enterocin P, a novel sec- dependent bacteriocin from Enterococcus faecium P13 with a broad antimicrobial spectrum.", Appl. Environ. Microbiol. 63:4321-4330(1997).
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End Note
Reference Manager
BibTeX
Gene structure
genome of Enterocin P

Gene idNameDescriptionLocation
BACGene276entPenterocin P precursor broad antimicrobial spectrum pediocin-like bacteriocin secreted by the generalsecretory pathway; sec-dependent bacteriocin173..388
BACGene277entPputative bacteriocin immunity protein orf2393..659
entPentP
Protein sequence
 ........10 ........20 ........30 ........40 ........50 
          |          |          |          |          | 
 ATRSYGNGVY CNNSKCWVNW GEAKENIAGI VISGWASGLA GMGH

Wheel representation
wheel representation of Enterocin P
Protein sequence annotations
Features of Enterocin P


FeaturePosition(s)LengthDescription
CHAIN1↔4444
Bacteriocin enterocin-P.
Feature identifier = PRO_5000053228.
DISULFID11↔166By similarity.
Composition
Hydrophobicity

Composition
Formula C202 H303 N59 O61 S3
Absent amino acids DFPQ
Common amino acids G
Mass (Da) 4648.91
Net charge +2
Isoelectric point 8.22
Basic residues 4
Acidic residues 2
Hydrophobic residues 15
Polar residues 22
Aliphatic residues 7
Tiny residues 17
Boman Index -33.68
Hydropathy Index -0.15
Aliphatic Index 66.59
Instability Index 13.31 (stable)
Half Life Mammalian : 4.4 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 19605 M-1 cm-1
Absorbance 280nm 455.93

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