Bacteriocin: thermophilin 13
Accession: BAC074
Classification
Class: Unclassified
Genetics
Gene: thermophilin 13 thmB
Producer and target organisms
Producer Organism: Streptococcus thermophilus [Gram-positive]
Taxonomy: BacteriaFirmicutes
Lactobacillales
Streptococcaceae
Streptococcus
Target organismsEnterococcus - Lactobacillus - Lactococcus - Leuconostoc
Uniprot and PDB links
UniProt Entry: O54455
PDB EntryUnknown
NUCLEOTIDE SEQUENCE, STRAIN=SFi13
MEDLINE=97306337;PubMed=9162062;DOI=10.1074/jbc.272.22.14277
Marciset O., Jeronimus-Stratingh M.C., Mollet B., Poolman B.
"Thermophilin 13, a nontypical antilisterial poration complex bacteriocin, that functions without a receptor.", J. Biol. Chem. 272:14277-14284(1997).
MEDLINE=97306337;PubMed=9162062;DOI=10.1074/jbc.272.22.14277
Marciset O., Jeronimus-Stratingh M.C., Mollet B., Poolman B.
"Thermophilin 13, a nontypical antilisterial poration complex bacteriocin, that functions without a receptor.", J. Biol. Chem. 272:14277-14284(1997).
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Gene structure
Gene id | Name | Description | Location |
BACGene249 | thmA | amphipathic pore-forming peptide precursor ThmA | 79..336 |
BACGene250 | thmB | enhancer peptide for thermophilin 13 precursor requires ThmB for full activity | 353..547 |
BACGene251 | thermophilin 13 operon | unknown hydrophobic peptide | 537..695 |
Protein sequence
........10 ........20 ........30 ........40 ........50 | | | | | QINWGSVVGH CIGGAIIGGA FSGGAAAGVG CLVGSGKAII NGL |
Wheel representation
Protein sequence annotations
Feature | Position(s) | Length | Description |
CHAIN | 1↔43 | 43 | enhancer peptide for thermophilin 13. Feature identifier = PRO_5000145346. |
Composition
Hydrophobicity
Composition
Formula | C172
H278
N50
O50
S2 |
Absent amino acids | DEMPRTY |
Common amino acids | G |
Mass (Da) | 3929.3 |
Net charge | +2 |
Isoelectric point | 8.24 |
Basic residues | 2 |
Acidic residues | 0 |
Hydrophobic residues | 20 |
Polar residues | 20 |
Aliphatic residues | 12 |
Tiny residues | 22 |
Boman Index | 47.24 |
Hydropathy Index | 1.02 |
Aliphatic Index | 113.49 |
Instability Index | 0.72 (stable) |
Half Life |
Mammalian : 0.8 hour Yeast : 10 min E. coli : >10 hour |
Extinction Coefficient | 5625 M-1 cm-1 |
Absorbance 280nm | 133.93 |
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