Bacteriocin: leucocin C

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Bacteriocin: leucocin C

Accession: BAC071

Classification
Genetics
Gene: Unidentified
Producer and target organisms

Producer Organism: Leuconostoc mesenteroides [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesLeuconostoc

Target organismslactic acid bacteria (LAB).

Description
Leuconostoc mesenteroides TA33a produces three bacteriocins leucocins A-, B- and C. A partial sequence of 36 amino acids of leucocin C-TA33a (4598 Da) was determined.Leucocin C-TA33a belongs to the class II bacteriocins having the consensus YGNGV motif. Circular dichroism spectra of the leucocins in aqueous solution and micellar SDS indicated that they undergo a structural transition when in a membrane-mimicking environment. Theoretical predictions from circular dichroism data suggest that leucocin C adopt a beta-structure (48%) in membrane-mimicking environments.
Uniprot and PDB links

UniProt Entry: P81053

PDB EntryUnknown

PROTEIN SEQUENCE, STRAIN=TA33a
MEDLINE=98274743;PubMed=9611809;
Papathanasopoulos M.A., Dykes G.A., Revol-Junelles A.-M., Delfour A., von Holy A., Hastings J.W.
"Sequence and structural relationships of leucocins A-, B- and C-TA33a from Leuconostoc mesenteroides TA33a.", Microbiology 144:1343-1348(1998).
PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
MEDLINE=22122295;PubMed=12127968;DOI=10.1016/S0006-291X(02)00769-6
Fimland G., Sletten K., Nissen-Meyer J.
"The complete amino acid sequence of the pediocin-like antimicrobial peptide leucocin C.", Biochem. Biophys. Res. Commun. 295:826-827(2002).
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Protein sequence
 ........10 ........20 ........30 ........40 ........50 
          |          |          |          |          | 
 KNYGNGVHCT KKGCSVDWGY AWTNIANNSV MNGLTGGNAG WHN

Wheel representation
wheel representation of leucocin C
Protein sequence annotations
Features of leucocin C


FeaturePosition(s)LengthDescription
CHAIN1↔4343
Bacteriocin leucocin-C.
Feature identifier = PRO_0000110575.
DISULFID9↔146By similarity.
CONFLICT22W -> A (in Ref. 2; AA sequence).
Composition
Hydrophobicity

Composition
Formula C198 H291 N61 O61 S3
Absent amino acids EFPQR
Common amino acids GN
Mass (Da) 4616.77
Net charge +4
Isoelectric point 8.77
Basic residues 5
Acidic residues 1
Hydrophobic residues 11
Polar residues 25
Aliphatic residues 5
Tiny residues 13
Boman Index -55.79
Hydropathy Index -0.67
Aliphatic Index 45.35
Instability Index 18.09 (stable)
Half Life Mammalian : 1.3 hour
Yeast : 3 min
E. coli : 2 min
Extinction Coefficient 19605 M-1 cm-1
Absorbance 280nm 466.79

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