Bacteriocin: thermophilin A
Accession: BAC068
Classification
Class: Unclassified
Genetics
Gene: thermophilin A
Producer and target organisms
Producer Organism: Streptococcus thermophilus [Gram-positive]
Taxonomy: BacteriaFirmicutes
Lactobacillales
Streptococcaceae
Streptococcus
Target organismsStreptococcus - Enterococcus - Lactococcus - Lactobacillus - Leuconostoc - Bifidobacterium - Listeria innocua - Listeria monocytogenes - Bacillus - Clostridium - Staphylococcus
Uniprot and PDB links
UniProt Entry: O54454
PDB EntryUnknown
NUCLEOTIDE SEQUENCE, STRAIN=SFi13
MEDLINE=97306337;PubMed=9162062;DOI=10.1074/jbc.272.22.14277
Marciset O., Jeronimus-Stratingh M.C., Mollet B., Poolman B.
"Thermophilin 13, a nontypical antilisterial poration complex bacteriocin, that functions without a receptor.", J. Biol. Chem. 272:14277-14284(1997).
MEDLINE=97306337;PubMed=9162062;DOI=10.1074/jbc.272.22.14277
Marciset O., Jeronimus-Stratingh M.C., Mollet B., Poolman B.
"Thermophilin 13, a nontypical antilisterial poration complex bacteriocin, that functions without a receptor.", J. Biol. Chem. 272:14277-14284(1997).
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Gene structure
Gene id | Name | Description | Location |
BACGene239 | thmA | amphipathic pore-forming peptide precursor ThmA | 79..336 |
BACGene240 | thmB | enhancer peptide for thermophilin 13 precursor requires ThmB for full activity | 353..547 |
BACGene241 | thermophilin 13 operon | unknown hydrophobic peptide | 537..695 |
Protein sequence
........10 ........20 ........30 ........40 ........50 | | | | | GALWGAPAGG VGALPGAFVG AHVGAIAGGF ACMGGMIGNK FN |
Wheel representation
Protein sequence annotations
Feature | Position(s) | Length | Description |
CHAIN | 1↔42 | 42 | amphipathic pore-forming peptide. Feature identifier = PRO_5000145345. |
Composition
Hydrophobicity
Composition
Formula | C173
H262
N48
O45
S3 |
Absent amino acids | DEQRSTY |
Common amino acids | G |
Mass (Da) | 3849.21 |
Net charge | +2 |
Isoelectric point | 8.55 |
Basic residues | 2 |
Acidic residues | 0 |
Hydrophobic residues | 20 |
Polar residues | 16 |
Aliphatic residues | 7 |
Tiny residues | 22 |
Boman Index | 54.07 |
Hydropathy Index | 0.87 |
Aliphatic Index | 79.29 |
Instability Index | 37.13 (stable) |
Half Life |
Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour |
Extinction Coefficient | 5500 M-1 cm-1 |
Absorbance 280nm | 134.15 |
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