Bacteriocin: sakacin-A

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Bacteriocin: sakacin-A

Accession: BAC066

Classification
Genetics
Gene: sapA; Synonyms=sakA
Uniprot and PDB links

UniProt Entry: P0A310 P35619

PDB EntryUnknown

NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE, STRAIN=Lb706
MEDLINE=93139766;PubMed=1487735;
Holck A.L., Axelsson L., Birkeland S.-E., Aukrust T., Blom H.
"Purification and amino acid sequence of sakacin A, a bacteriocin from Lactobacillus sake Lb706.", J. Gen. Microbiol. 138:2715-2720(1992).
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=Lb706
MEDLINE=95238285;PubMed=7721704;
Axelsson L., Holck A.
"The genes involved in production of and immunity to sakacin A, a bacteriocin from Lactobacillus sake Lb706.", J. Bacteriol. 177:2125-2137(1995).
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Gene structure
genome of sakacin-A

Gene idNameDescriptionLocation
BACGene231orf1complement(5..268)
BACGene232saiAsakacin A immunity factor start codon ttgcomplement(653..925)
BACGene233sapAsakacin A precursor previously designated sakAcomplement(940..1119)
BACGene234orf42526..2663
BACGene235sapKhistidine kinase putative; previously designated sakB2724..4010
BACGene236sapRresponse regulator putative4026..4769
BACGene237sapTABC exporter putative4842..7001
BACGene238sapEaccessory factor for ABC exporter putative7020..8405
orf1saiAsapAorf4sapKsapRsapTsapE
Protein sequence
 ........10 ........20 ........30 ........40 ........50 
          |          |          |          |          | 
 ARSYGNGVYC NNKKCWVNRG EATQSIIGGM ISGWASGLAG M

Wheel representation
wheel representation of sakacin-A
Protein sequence annotations
Features of sakacin-A


FeaturePosition(s)LengthDescription
CHAIN1↔4141
Bacteriocin sakacin-A.
Feature identifier = PRO_0000002750.
DISULFID10↔156By similarity.
Composition
Hydrophobicity

Composition
Formula C184 H288 N56 O56 S4
Absent amino acids DFHP
Common amino acids G
Mass (Da) 4327.58
Net charge +3
Isoelectric point 9.37
Basic residues 4
Acidic residues 1
Hydrophobic residues 12
Polar residues 21
Aliphatic residues 6
Tiny residues 16
Boman Index -41.86
Hydropathy Index -0.19
Aliphatic Index 61.95
Instability Index 27.63 (stable)
Half Life Mammalian : 4.4 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 14105 M-1 cm-1
Absorbance 280nm 352.63

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