Bacteriocin: curvacin-A

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Bacteriocin: curvacin-A

Accession: BAC065

Classification
Genetics
Gene: curA
Uniprot and PDB links

UniProt Entry: P0A311

PDB Entry2A2B resolved by NMR.

NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=LTH1174
MEDLINE=94058500;PubMed=7694558;DOI=10.1007/BF00292077
Tichaczek P.S., Vogel R.F., Hammes W.P.
"Cloning and sequencing of curA encoding curvacin A, the bacteriocin produced by Lactobacillus curvatus LTH1174.", Arch. Microbiol. 160:279-283(1993).
PRELIMINARY PARTIAL PROTEIN SEQUENCE OF 19-59, STRAIN=LTH1174
Tichaczek P.S., Nissen-Meyer J., Nes I.F., Vogel R.F., Hammes W.P.
"Characterization of the bacteriocins curvacin A from Lactobacillus curvatus LTH1174 and sakacin P from L. sake LTH673.", Syst. Appl. Microbiol. 15:460-465(1992).
Mutational Analysis / Structure-function relationships
PubMed=18791005;DOI=10.1128/AEM.01068-08
Haugen HS, Kristiansen PE, Fimland G, Nissen-Meyer J
"Mutational Analysis of the Class IIa Bacteriocin Curvacin A and Its Orientation in Target Cell Membranes.", Appl. Environ. Microbiol. 74(21):6766-73 (2008).
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Gene structure
genome of curvacin-A

Gene idNameDescriptionLocation
BACGene229curApre-curvacinA252..431
BACGene230curAORFB586..741
curAcurA
Protein sequence
 ........10 ........20 ........30 ........40 ........50 
          |          |          |          |          | 
 ARSYGNGVYC NNKKCWVNRG EATQSIIGGM ISGWASGLAG M

Wheel representation
wheel representation of curvacin-A
3D Structure
Protein sequence annotations
Features of curvacin-A


FeaturePosition(s)LengthDescription
CHAIN1↔4141
Bacteriocin curvacin-A.
Feature identifier = PRO_0000002748.
DISULFID10↔156
CONFLICT2R -> C (in Ref. 2; AA sequence).
CONFLICT15C -> S (in Ref. 2; AA sequence).
STRAND4↔63
STRAND11↔144
HELIX19↔246
HELIX29↔3911
Composition
Hydrophobicity

Composition
Formula C184 H288 N56 O56 S4
Absent amino acids DFHP
Common amino acids G
Mass (Da) 4327.58
Net charge +3
Isoelectric point 9.37
Basic residues 4
Acidic residues 1
Hydrophobic residues 12
Polar residues 21
Aliphatic residues 6
Tiny residues 16
Boman Index -41.86
Hydropathy Index -0.19
Aliphatic Index 61.95
Instability Index 27.63 (stable)
Half Life Mammalian : 4.4 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 14105 M-1 cm-1
Absorbance 280nm 352.63

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