Bacteriocin: lactococcin MMFII
Accession: BAC060
Classification
Class: class IIA/YGNGV
Genetics
Gene: Unidentified
Producer and target organisms
Producer Organism: Lactococcus lactis subsp (Streptococcus lactis), lactis [Gram-positive]
Taxonomy: Bacteria
FirmicutesLactobacillalesStreptococcaceaeLactococcus
Target organismsEnterococcus - Lactobacillus - Lactococcus - Listeria monocytogenes - Listeria ivanovii
Description
Mode of action:
NOTE=Ref.1.
NOTE=Ref.1.
Uniprot and PDB links
UniProt Entry: P83002
PDB EntryUnknown
PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY, STRAIN=MMFII
MEDLINE=21585558;PubMed=11728715;
Ferchichi M., Frere J., Mabrouk K., Manai M.
"Lactococcin MMFII, a novel class IIa bacteriocin produced by Lactococcus lactis MMFII, isolated from a Tunisian dairy product.", FEMS Microbiol. Lett. 205:49-55(2001).
MEDLINE=21585558;PubMed=11728715;
Ferchichi M., Frere J., Mabrouk K., Manai M.
"Lactococcin MMFII, a novel class IIa bacteriocin produced by Lactococcus lactis MMFII, isolated from a Tunisian dairy product.", FEMS Microbiol. Lett. 205:49-55(2001).
SYNTHESIS, AND 3D-STRUCTURE MODELING, STRAIN=MMFII
MEDLINE=21565876;PubMed=11708769;DOI=10.1006/bbrc.2001.5908
Ferchichi M., Fathallah M., Mansuelle P., Rochat H., Sabatier J.-M., Manai M., Mabrouk K.
"Chemical synthesis, molecular modeling, and antimicrobial activity of a novel bacteriocin, MMFII.", Biochem. Biophys. Res. Commun. 289:13-18(2001).
MEDLINE=21565876;PubMed=11708769;DOI=10.1006/bbrc.2001.5908
Ferchichi M., Fathallah M., Mansuelle P., Rochat H., Sabatier J.-M., Manai M., Mabrouk K.
"Chemical synthesis, molecular modeling, and antimicrobial activity of a novel bacteriocin, MMFII.", Biochem. Biophys. Res. Commun. 289:13-18(2001).
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Protein sequence
| ........10 ........20 ........30 ........40 | | | | TSYGNGVHCN KSKCWIDVSE LETYKAGTVS NPKDILW |
Wheel representation
Protein sequence annotations
| Feature | Position(s) | Length | Description |
| PEPTIDE | 1↔37 | 37 | Bacteriocin lactococcin MMFII. Feature identifier = PRO_0000044637. |
| DISULFID | 9↔14 | 6 |
Composition
Hydrophobicity
Composition
| Formula | C183
H280
N48
O58
S2 |
| Absent amino acids | FMQR |
| Common amino acids | KS |
| Mass (Da) | 4163.25 |
| Net charge | +1 |
| Isoelectric point | 7.25 |
| Basic residues | 5 |
| Acidic residues | 4 |
| Hydrophobic residues | 10 |
| Polar residues | 17 |
| Aliphatic residues | 7 |
| Tiny residues | 8 |
| Boman Index | -55.78 |
| Hydropathy Index | -0.54 |
| Aliphatic Index | 68.38 |
| Instability Index | 27.62 (stable) |
| Half Life |
Mammalian : 7.2 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 14105 M-1 cm-1 |
| Absorbance 280nm | 391.81 |
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