Bacteriocin: Enterocin Q

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Bacteriocin: Enterocin Q

Accession: BAC052

Classification
Class: Class IIc
Genetics
Gene: entQ
Producer and target organisms
Description
Enterococcus faecium L50 produces, in addition to EntL50, the sec-dependent pediocin-like enterocin P (EntP), and an unmodified non-pediocin-like bacteriocin, termed enterocin Q (EntQ), synthesized without an N-terminal leader sequence or signal peptide. Note=Ref1.
NUCLEOTIDE SEQUENCE, STRAIN=L50
MEDLINE=20528333;PubMed=11073927;DOI=10.1128/JB.182.23.6806-6814.2000
Cintas L.M., Casaus P., Herranz C., Havarstein L.S., Holo H., Hernandez P.E., Nes I.F.
"Biochemical and genetic evidence that Enterococcus faecium L50 produces enterocins L50A and L50B, the sec-dependent enterocin P, and a novel bacteriocin secreted without an N-terminal extension termed enterocin Q.", J. Bacteriol. 182:6806-6814(2000).
NUCLEOTIDE SEQUENCE, STRAIN=L50
Cintas L.M., Casaus P., Herranz C., Havarstein L.S., Holo H., Hernandez P.E., Nes I.F.
"", Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
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End Note
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BibTeX
Gene structure
genome of Enterocin Q

Gene idNameDescriptionLocation
BACGene186entqAEntQ leader-less bacteriocin; enterocin Qcomplement(155..259)
BACGene187entqBEntQB EntQ ABC-transporter340..2058
BACGene188entqCEntQC EntQ immunity protein2069..2272
BACGene189entqCputative mobilization protein ORF42686..3012
BACGene190entqCputative mobilization protein ORF5; contains relaxase/mobilization nuclease domain2994..3908
BACGene191entqChypothetical protein ORF63700..4146
BACGene192entqChypothetical protein ORF74148..4837
BACGene193entqCputative plasmid replication protein ORF85690..6427
BACGene194entqCputative plasmid replication protein ORF96455..6991
BACGene195entqChypothetical protein ORF107007..7177
entqAentqBentqCentqCentqCentqCentqCentqCentqCentqC
Protein sequence
 ........10 ........20 ........30 ........40 
          |          |          |          | 
 MNFLKNGIAK WMTGAELQAY KKKYGCLPWE KISC

Wheel representation
wheel representation of Enterocin Q
Composition
Hydrophobicity

Composition
Formula C181 H281 N45 O46 S4
Absent amino acids DHRV
Common amino acids K
Mass (Da) 3970.31
Net charge +4
Isoelectric point 9.78
Basic residues 6
Acidic residues 2
Hydrophobic residues 11
Polar residues 11
Aliphatic residues 5
Tiny residues 7
Boman Index -24.24
Hydropathy Index -0.36
Aliphatic Index 66.18
Instability Index 21.66 (stable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 14105 M-1 cm-1
Absorbance 280nm 427.42

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