Bacteriocin: leucocin-B

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Bacteriocin: leucocin-B

Accession: BAC042

Classification
Class: Unclassified
Genetics
Gene: Unidentified
Producer and target organisms

Producer Organism: Leuconostoc mesenteroides [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesLeuconostoc

Target organismswide spectrum of lactic acid bacteria.

Description
Leuconostoc mesenteroides TA33a produces three bacteriocins leucocins A-, B- and C. Leucocin B consists of 31 amino acid residues, with a molecular mass of 3466 Da. Leucocin B-TA33a does not belong to the pediocin family of bacteriocins, but shares 62% homology with mesenterocin 52B.
Circular dichroism spectra of the leucocins in aqueous solution and micellar SDS indicated that they undergo a structural transition when in a membrane-mimicking environment. Theoretical predictions from circular dichroism data suggest that leucocins B adopt a beta-structure (48%) in membrane-mimicking environments.
Uniprot and PDB links

UniProt Entry: P81052

PDB EntryUnknown

PROTEIN SEQUENCE, STRAIN=TA33a
MEDLINE=98274743;PubMed=9611809;
Papathanasopoulos M.A., Dykes G.A., Revol-Junelles A.-M., Delfour A., von Holy A., Hastings J.W.
"Sequence and structural relationships of leucocins A-, B- and C-TA33a from Leuconostoc mesenteroides TA33a.", Microbiology 144:1343-1348(1998).
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Protein sequence
 ........10 ........20 ........30 ........40 
          |          |          |          | 
 KGKGFWSWAS KATSWLTGPQ QPGSPLLKKH R

Wheel representation
wheel representation of leucocin-B
Protein sequence annotations
Features of leucocin-B


FeaturePosition(s)LengthDescription
PEPTIDE1↔3131
Bacteriocin leucocin-B.
Feature identifier = PRO_0000044639.
Composition
Hydrophobicity

Composition
Formula C161 H246 N46 O40
Absent amino acids CDEIMNVY
Common amino acids K
Mass (Da) 3484.5
Net charge +7
Isoelectric point 12.05
Basic residues 7
Acidic residues 0
Hydrophobic residues 9
Polar residues 10
Aliphatic residues 3
Tiny residues 10
Boman Index -45.04
Hydropathy Index -0.97
Aliphatic Index 44.19
Instability Index 27.93 (stable)
Half Life Mammalian : 1.3 hour
Yeast : 3 min
E. coli : 2 min
Extinction Coefficient 16500 M-1 cm-1
Absorbance 280nm 550

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