Bacteriocin: Epicidin 280

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Bacteriocin: Epicidin 280

Accession: BAC040

Classification
Class: Lantibiotic
Genetics
Gene: eciA
Producer and target organisms

Producer Organism: Staphylococcus epidermidis [Gram-positive]

Taxonomy: BacteriaFirmicutesBacillalesStaphylococcus

Target organismsUnavailable data

Description
Mode of action:
Lanthionine-containing peptide antibiotic (lantibiotic) Transiently and partially depolarizes the transmembrane electrical potential and pH gradient of susceptible cells, inhibits the uptake of amino acids and depletes the intracellular ATP pool.

Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.
Uniprot and PDB links

UniProt Entry: O54220

PDB EntryUnknown

NUCLEOTIDE SEQUENCE, STRAIN=BN 280
MEDLINE=98394975;PubMed=9726851;
Heidrich C., Pag U., Josten M., Metzger J., Jack R.W., Bierbaum G., Jung G., Sahl H.G.
"Isolation, characterization and sequence of the novel lantibiotic epicidin 280 and its biosynthetic gene cluster.", Appl. Environ. Microbiol. 64:3140-3146(1998).
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Gene structure
genome of Epicidin 280

Gene idNameDescriptionLocation
BACGene143tnp1transposasecomplement(1..30)
BACGene144eciOoxidoreductase874..1617
BACGene145eciIEciI protein producer-self-protection1690..1878
BACGene146eciAepicidin 280 antimicrobial1940..2110
BACGene147eciPprotease subtilisin-like leader peptidase2194..3096
BACGene148eciBEciB protein3083..6013
BACGene149eciCEciC protein5998..7191
tnp1eciOeciIeciAeciPeciBeciC
Protein sequence
 ........10 ........20 ........30 ........40 
          |          |          |          | 
 SLGPAIKATR QVCPKATRFV TVSCKKSDCQ

Wheel representation
wheel representation of Epicidin 280
Protein sequence annotations
Features of Epicidin 280


FeaturePosition(s)LengthDescription
CHAIN1↔3030
epicidin 280.
Feature identifier = PRO_5000147185.
Composition
Hydrophobicity

Composition
Formula C137 H236 N42 O41 S3
Absent amino acids EHMNWY
Common amino acids K
Mass (Da) 3242.31
Net charge +5
Isoelectric point 10.35
Basic residues 6
Acidic residues 1
Hydrophobic residues 9
Polar residues 10
Aliphatic residues 5
Tiny residues 7
Boman Index -54.6
Hydropathy Index -0.22
Aliphatic Index 65
Instability Index 29.11 (stable)
Half Life Mammalian : 1.9 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 125 M-1 cm-1
Absorbance 280nm 4.31

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