Bacteriocin: streptococcin A-M49
Accession: BAC031
Classification
Class: Lantibiotic
Genetics
Gene: scnA
Producer and target organisms
Producer Organism: Streptococcus pyogenes serotype M49 [Gram-positive]
Taxonomy: Bacteria
FirmicutesLactobacillalesStreptococcaceaeStreptococcus
Target organismsactive on certain Gram-positive bacteria
Description
Mode of action:
Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores (By similarity). extracellular form (By similarity).
Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor (By similarity). streptococcin A-M49, their coding sequences only differ in the propeptide region.
Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores (By similarity). extracellular form (By similarity).
Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor (By similarity). streptococcin A-M49, their coding sequences only differ in the propeptide region.
Uniprot and PDB links
UniProt Entry: Q54957
PDB EntryUnknown
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=GT9538 / Serotype M49
MEDLINE=95085281;PubMed=7993103;
Hynes W.L., Friend V.L., Ferretti J.J.
"Duplication of the lantibiotic structural gene in M-type 49 group A streptococcus strains producing streptococcin A-M49.", Appl. Environ. Microbiol. 60:4207-4209(1994).
MEDLINE=95085281;PubMed=7993103;
Hynes W.L., Friend V.L., Ferretti J.J.
"Duplication of the lantibiotic structural gene in M-type 49 group A streptococcus strains producing streptococcin A-M49.", Appl. Environ. Microbiol. 60:4207-4209(1994).
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Gene structure
| Gene id | Name | Description | Location |
| BACGene116 | scnA | streptococcin A-M49 putative antibacterial protein precursor; putative | 115..270 |
| BACGene117 | scnA | streptococcin A-M49 putative antibacterial protein precursor; putative | 301..456 |
Protein sequence
| ........10 ........20 ........30 | | | GKNGVFKTIS HECHLNTWAF LATCCS |
Wheel representation
Protein sequence annotations
| Feature | Position(s) | Length | Description |
| PEPTIDE | 1↔26 | 26 | Lantibiotic streptococcin A-M49. Feature identifier = PRO_0000017137. |
| Modified residue | 23 | 2,3-didehydrobutyrine (By similarity). | |
| Cross-link | 8↔13 | 6 | Beta-methyllanthionine (Thr-Cys) (Bysimilarity). |
| Cross-link | 10↔24 | 15 | Lanthionine (Ser-Cys) (By similarity). |
| Cross-link | 17↔25 | 9 | Beta-methyllanthionine (Thr-Cys) (Bysimilarity). |
Composition
Hydrophobicity
Composition
| Formula | C126
H191
N35
O36
S3 |
| Absent amino acids | DMPQRY |
| Common amino acids | CT |
| Mass (Da) | 2886.73 |
| Net charge | +3 |
| Isoelectric point | 8.07 |
| Basic residues | 4 |
| Acidic residues | 1 |
| Hydrophobic residues | 9 |
| Polar residues | 12 |
| Aliphatic residues | 4 |
| Tiny residues | 6 |
| Boman Index | -18.59 |
| Hydropathy Index | 0.11 |
| Aliphatic Index | 63.85 |
| Instability Index | 9.4 (stable) |
| Half Life |
Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 5625 M-1 cm-1 |
| Absorbance 280nm | 225 |
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