Bacteriocin: streptococcin A-M49

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Bacteriocin: streptococcin A-M49

Accession: BAC031

Classification
Class: Lantibiotic
Genetics
Gene: scnA
Producer and target organisms

Producer Organism: Streptococcus pyogenes serotype M49 [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesStreptococcaceaeStreptococcus

Target organismsactive on certain Gram-positive bacteria

Description
Mode of action:
Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores (By similarity). extracellular form (By similarity).

Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor (By similarity). streptococcin A-M49, their coding sequences only differ in the propeptide region.
Uniprot and PDB links

UniProt Entry: Q54957

PDB EntryUnknown

NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=GT9538 / Serotype M49
MEDLINE=95085281;PubMed=7993103;
Hynes W.L., Friend V.L., Ferretti J.J.
"Duplication of the lantibiotic structural gene in M-type 49 group A streptococcus strains producing streptococcin A-M49.", Appl. Environ. Microbiol. 60:4207-4209(1994).
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Gene structure
genome of streptococcin A-M49

Gene idNameDescriptionLocation
BACGene116scnAstreptococcin A-M49 putative antibacterial protein precursor; putative115..270
BACGene117scnAstreptococcin A-M49 putative antibacterial protein precursor; putative301..456
scnAscnA
Protein sequence
 ........10 ........20 ........30 
          |          |          | 
 GKNGVFKTIS HECHLNTWAF LATCCS

Wheel representation
wheel representation of streptococcin A-M49
Protein sequence annotations
Features of streptococcin A-M49

T
FeaturePosition(s)LengthDescription
PEPTIDE1↔2626
Lantibiotic streptococcin A-M49.
Feature identifier = PRO_0000017137.
Modified residue232,3-didehydrobutyrine (By similarity).
Cross-link8↔136Beta-methyllanthionine (Thr-Cys) (Bysimilarity).
Cross-link10↔2415Lanthionine (Ser-Cys) (By similarity).
Cross-link17↔259Beta-methyllanthionine (Thr-Cys) (Bysimilarity).
Composition
Hydrophobicity

Composition
Formula C126 H191 N35 O36 S3
Absent amino acids DMPQRY
Common amino acids CT
Mass (Da) 2886.73
Net charge +3
Isoelectric point 8.07
Basic residues 4
Acidic residues 1
Hydrophobic residues 9
Polar residues 12
Aliphatic residues 4
Tiny residues 6
Boman Index -18.59
Hydropathy Index 0.11
Aliphatic Index 63.85
Instability Index 9.4 (stable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 5625 M-1 cm-1
Absorbance 280nm 225

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