Bacteriocin: streptococcin A-FF22

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Bacteriocin: streptococcin A-FF22

Accession: BAC030

Classification
Class: Lantibiotic
Genetics
Gene: scnA
Producer and target organisms
Description
Mode of action:
Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. extracellular form.

Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.
Uniprot and PDB links

UniProt Entry: P36501

PDB EntryUnknown

NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=FF22
MEDLINE=93319301;PubMed=8328813;
Hynes W.L., Ferretti J.J., Tagg J.R.
"Cloning of the gene encoding Streptococcin A-FF22, a novel lantibiotic produced by Streptococcus pyogenes, and determination of its nucleotide sequence.", Appl. Environ. Microbiol. 59:1969-1971(1993).
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=FF22
McLaughlin R.E., Hynes W.L.
"", Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
PROTEIN SEQUENCE OF 26-51, STRAIN=FF22
MEDLINE=94170794;PubMed=8125103;
Jack R.W., Carne A., Metzger J., Stefanovic S., Sahl H.-G., Jung G., Tagg J.R.
"Elucidation of the structure of SA-FF22, a lanthionine-containing antibacterial peptide produced by Streptococcus pyogenes strain FF22.", Eur. J. Biochem. 220:455-462(1994).
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Gene structure
genome of streptococcin A-FF22

Gene idNameDescriptionLocation
BACGene106scnKScnKcomplement(244..1605)
BACGene107scnRScnRcomplement(1623..2321)
BACGene108scnAstreptococcin A-FF22 precursor antibacterial lantibiotic2519..2674
BACGene109scnA1ScnA12874..3029
BACGene110scnMScnM3050..5833
BACGene111scnTScnT5856..7925
BACGene112scnFScnF8037..8936
BACGene113scnEScnE8948..9712
BACGene114scnGScnG9728..10441
BACGene115tnpATnpAcomplement(10555..11650)
scnKscnRscnAscnA1scnMscnTscnFscnEscnGtnpA
Protein sequence
 ........10 ........20 ........30 
          |          |          | 
 GKNGVFKTIS HECHLNTWAF LATCCS

Wheel representation
wheel representation of streptococcin A-FF22
Protein sequence annotations
Features of streptococcin A-FF22

T
FeaturePosition(s)LengthDescription
PEPTIDE1↔2626
Lantibiotic streptococcin A-FF22.
Feature identifier = PRO_0000017135.
Modified residue232,3-didehydrobutyrine (By similarity).
Cross-link8↔136Beta-methyllanthionine (Thr-Cys) (Bysimilarity).
Cross-link10↔2415Lanthionine (Ser-Cys) (By similarity).
Cross-link17↔259Beta-methyllanthionine (Thr-Cys) (Bysimilarity).
Composition
Hydrophobicity

Composition
Formula C126 H191 N35 O36 S3
Absent amino acids DMPQRY
Common amino acids CT
Mass (Da) 2886.73
Net charge +3
Isoelectric point 8.07
Basic residues 4
Acidic residues 1
Hydrophobic residues 9
Polar residues 12
Aliphatic residues 4
Tiny residues 6
Boman Index -18.59
Hydropathy Index 0.11
Aliphatic Index 63.85
Instability Index 9.4 (stable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 5625 M-1 cm-1
Absorbance 280nm 225

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