Bacteriocin: acidocin 8912
Accession: BAC029
Classification
Class: Unclassified
Genetics
Gene: acdT
Producer and target organisms
Producer Organism: Lactobacillus acidophilus [Gram-positive]
Taxonomy: Bacteria
FirmicutesLactobacillalesLactobacillaceaeLactobacillus
Target organismsUnavailable data
Description
Mode of action:
Has a bactericidal effect on sensitive cells but not a bacteriolytic effect.
Has a bactericidal effect on sensitive cells but not a bacteriolytic effect.
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=TK8912
MEDLINE=96140009;PubMed=8554765;
Kanatani K., Tahara T., Oshimura M., Sano K., Umezawa C.
"Cloning and nucleotide sequence of the gene for acidocin 8912, a bacteriocin from Lactobacillus acidophilus TK8912.", Lett. Appl. Microbiol. 21:384-386(1995).
MEDLINE=96140009;PubMed=8554765;
Kanatani K., Tahara T., Oshimura M., Sano K., Umezawa C.
"Cloning and nucleotide sequence of the gene for acidocin 8912, a bacteriocin from Lactobacillus acidophilus TK8912.", Lett. Appl. Microbiol. 21:384-386(1995).
[Ref. 2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=TK8912
Nakachi I.
"", Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Nakachi I.
"", Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
PROTEIN SEQUENCE OF 21-44, STRAIN=TK8912
MEDLINE=93005074;PubMed=1368836;
Tahara T., Kanatani K., Yoshida K., Miura H., Sakamoto M., Oshimura M.
"Purification and some properties of acidocin 8912, a novel bacteriocin produced by Lactobacillus acidophilus TK8912.", Biosci. Biotechnol. Biochem. 56:1212-1215(1992).
MEDLINE=93005074;PubMed=1368836;
Tahara T., Kanatani K., Yoshida K., Miura H., Sakamoto M., Oshimura M.
"Purification and some properties of acidocin 8912, a novel bacteriocin produced by Lactobacillus acidophilus TK8912.", Biosci. Biotechnol. Biochem. 56:1212-1215(1992).
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Gene structure
| Gene id | Name | Description | Location |
| BACGene91 | hypothetical protein | complement(297..722) | |
| BACGene92 | RepA2 | replication protein A | 2113..2292 |
| BACGene93 | RepA1 | replication protein A | 2934..3782 |
| BACGene94 | RepB | replication protein B | complement(3968..4477) |
| BACGene95 | acd M | acidocin M Start codon is not identified. | 5367..5618 |
| BACGene96 | acd M | hypothetical protein | 5618..5929 |
| BACGene97 | acd M | ABC transporter | 6385..8478 |
| BACGene98 | acd M | accessory protein | 8471..9865 |
| BACGene99 | acd T | acidocin 8912 | 10024..10164 |
| BACGene100 | acd T | hypothetical protein | 10496..10873 |
| BACGene101 | acd T | transposase | complement(11042..11428) |
| BACGene102 | acd T | transposase | complement(11507..11725) |
| BACGene103 | acd T | hypothetical protein | complement(12021..12413) |
| BACGene104 | acd T | hypothetical protein | 12703..13467 |
| BACGene105 | acd T | hypothetical protein | 13564..13905 |
Protein sequence
| ........10 ........20 ........30 | | | KTHYPTNAWK SLWKGFWESL RYTDGF |
Wheel representation
Protein sequence annotations
| Feature | Position(s) | Length | Description |
| PEPTIDE | 1↔26 | 26 | Bacteriocin acidocin 8912. Feature identifier = PRO_0000002763. |
| CONFLICT | 13 | W -> R (in Ref. 3; AA sequence). |
Composition
Hydrophobicity
Composition
| Formula | C154
H212
N38
O39
|
| Absent amino acids | CIMQV |
| Common amino acids | KTW |
| Mass (Da) | 3238.01 |
| Net charge | +3 |
| Isoelectric point | 9.87 |
| Basic residues | 5 |
| Acidic residues | 2 |
| Hydrophobic residues | 8 |
| Polar residues | 10 |
| Aliphatic residues | 2 |
| Tiny residues | 5 |
| Boman Index | -46.71 |
| Hydropathy Index | -1.01 |
| Aliphatic Index | 33.85 |
| Instability Index | 39.97 (stable) |
| Half Life |
Mammalian : 1.3 hour Yeast : 3 min E. coli : 2 min |
| Extinction Coefficient | 19480 M-1 cm-1 |
| Absorbance 280nm | 779.2 |
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