Bacteriocin: acidocin 8912
Accession: BAC029
Classification
Class: Unclassified
Genetics
Gene: acdT
Producer and target organisms
Producer Organism: Lactobacillus acidophilus [Gram-positive]
Taxonomy: BacteriaFirmicutes
Lactobacillales
Lactobacillaceae
Lactobacillus
Target organismsUnavailable data
Description
Mode of action:
Has a bactericidal effect on sensitive cells but not a bacteriolytic effect.
Has a bactericidal effect on sensitive cells but not a bacteriolytic effect.
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=TK8912
MEDLINE=96140009;PubMed=8554765;
Kanatani K., Tahara T., Oshimura M., Sano K., Umezawa C.
"Cloning and nucleotide sequence of the gene for acidocin 8912, a bacteriocin from Lactobacillus acidophilus TK8912.", Lett. Appl. Microbiol. 21:384-386(1995).
MEDLINE=96140009;PubMed=8554765;
Kanatani K., Tahara T., Oshimura M., Sano K., Umezawa C.
"Cloning and nucleotide sequence of the gene for acidocin 8912, a bacteriocin from Lactobacillus acidophilus TK8912.", Lett. Appl. Microbiol. 21:384-386(1995).
[Ref. 2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=TK8912
Nakachi I.
"", Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Nakachi I.
"", Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
PROTEIN SEQUENCE OF 21-44, STRAIN=TK8912
MEDLINE=93005074;PubMed=1368836;
Tahara T., Kanatani K., Yoshida K., Miura H., Sakamoto M., Oshimura M.
"Purification and some properties of acidocin 8912, a novel bacteriocin produced by Lactobacillus acidophilus TK8912.", Biosci. Biotechnol. Biochem. 56:1212-1215(1992).
MEDLINE=93005074;PubMed=1368836;
Tahara T., Kanatani K., Yoshida K., Miura H., Sakamoto M., Oshimura M.
"Purification and some properties of acidocin 8912, a novel bacteriocin produced by Lactobacillus acidophilus TK8912.", Biosci. Biotechnol. Biochem. 56:1212-1215(1992).
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Gene structure
Gene id | Name | Description | Location |
BACGene91 | hypothetical protein | complement(297..722) | |
BACGene92 | RepA2 | replication protein A | 2113..2292 |
BACGene93 | RepA1 | replication protein A | 2934..3782 |
BACGene94 | RepB | replication protein B | complement(3968..4477) |
BACGene95 | acd M | acidocin M Start codon is not identified. | 5367..5618 |
BACGene96 | acd M | hypothetical protein | 5618..5929 |
BACGene97 | acd M | ABC transporter | 6385..8478 |
BACGene98 | acd M | accessory protein | 8471..9865 |
BACGene99 | acd T | acidocin 8912 | 10024..10164 |
BACGene100 | acd T | hypothetical protein | 10496..10873 |
BACGene101 | acd T | transposase | complement(11042..11428) |
BACGene102 | acd T | transposase | complement(11507..11725) |
BACGene103 | acd T | hypothetical protein | complement(12021..12413) |
BACGene104 | acd T | hypothetical protein | 12703..13467 |
BACGene105 | acd T | hypothetical protein | 13564..13905 |
Protein sequence
........10 ........20 ........30 | | | KTHYPTNAWK SLWKGFWESL RYTDGF |
Wheel representation
Protein sequence annotations
Feature | Position(s) | Length | Description |
PEPTIDE | 1↔26 | 26 | Bacteriocin acidocin 8912. Feature identifier = PRO_0000002763. |
CONFLICT | 13 | W -> R (in Ref. 3; AA sequence). |
Composition
Hydrophobicity
Composition
Formula | C154
H212
N38
O39
|
Absent amino acids | CIMQV |
Common amino acids | KTW |
Mass (Da) | 3238.01 |
Net charge | +3 |
Isoelectric point | 9.87 |
Basic residues | 5 |
Acidic residues | 2 |
Hydrophobic residues | 8 |
Polar residues | 10 |
Aliphatic residues | 2 |
Tiny residues | 5 |
Boman Index | -46.71 |
Hydropathy Index | -1.01 |
Aliphatic Index | 33.85 |
Instability Index | 39.97 (stable) |
Half Life |
Mammalian : 1.3 hour Yeast : 3 min E. coli : 2 min |
Extinction Coefficient | 19480 M-1 cm-1 |
Absorbance 280nm | 779.2 |
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