Bacteriocin: Variacin

Default view

Bacteriocin: Variacin

Accession: BAC028

Classification
Genetics
Gene: Unidentified
Description
Mode of action:
Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.
Uniprot and PDB links

UniProt Entry: Q50848

PDB EntryUnknown

NUCLEOTIDE SEQUENCE.
MEDLINE=96209245;PubMed=8633879;
Pridmore D., Rekhif N., Pittet A.C., Suri B., Mollet B.
"Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to the lacticin 481 of Lactococcus lactis.", Appl. Environ. Microbiol. 62:1799-1802(1996).
NUCLEOTIDE SEQUENCE.
Pridmore R.D.
"", Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
Loading...
End Note
Reference Manager
BibTeX
Gene structure
genome of Variacin

Gene idNameDescriptionLocation
BACGene90bacteriocin88..231
Protein sequence
 ........10 ........20 ........30 
          |          |          | 
 GSGVIPTISH ECHMNSFQFV FTCCS

Wheel representation
wheel representation of Variacin
Protein sequence annotations
Features of Variacin


FeaturePosition(s)LengthDescription
CHAIN1↔2525
Potential.
Feature identifier = PRO_5000146696.
Composition
Hydrophobicity

Composition
Formula C118 H175 N31 O36 S4
Absent amino acids ADKLRWY
Common amino acids S
Mass (Da) 2750.51
Net charge +1
Isoelectric point 6.47
Basic residues 2
Acidic residues 1
Hydrophobic residues 7
Polar residues 12
Aliphatic residues 4
Tiny residues 6
Boman Index -12.12
Hydropathy Index 0.45
Aliphatic Index 54.4
Instability Index 36.05 (stable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 125 M-1 cm-1
Absorbance 280nm 5.21

Users comments for Variacin

No comments found

Login or register to submit a comment for Variacin.