Bacteriocin: Variacin
Accession: BAC028
Producer Organism: Micrococcus varians [Gram-positive]
Taxonomy: BacteriaActinobacteria
Actinobacteridae
Actinomycetales
Micrococcineae
Micrococcaceae
Kocuria
Target organismsLactobacillus helveticus - Lactobacillus bulgaricus - Lactobacillus lactis - Lactobacillus delbrueckii - Lactobacillus acidophilus - Lactobacillus plantarum - Lactobacillus sakei (LSK) - Lactobacillus curvatus - Leuconostoc mesenteroides - Streptococcus thermophilus - Lactococcus lactis (SL2) - Micrococcus varians (MCV8) - Micrococcus varians (MCV12) - Enterococcus faecalis - Enterococcus faecium - Listeria innocua - Listeria monocytogenes - Listeria welhia - Clostridium botulinum - Clostridium sp - Staphylococcus aureus - Staphylococcus carnosus - Staphylococcus saprophyticus - Staphylococcus sp - Bacillus subtilis - Bacillus cereus - Bacillus pumilis -
Note: Inactive against Gram-negative bacteria
Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.
UniProt Entry: Q50848
PDB EntryUnknown
MEDLINE=96209245;PubMed=8633879;
Pridmore D., Rekhif N., Pittet A.C., Suri B., Mollet B.
"Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to the lacticin 481 of Lactococcus lactis.", Appl. Environ. Microbiol. 62:1799-1802(1996).
Gene id | Name | Description | Location |
BACGene90 | bacteriocin | 88..231 |
........10 ........20 ........30 | | | GSGVIPTISH ECHMNSFQFV FTCCS |
Feature | Position(s) | Length | Description |
CHAIN | 1↔25 | 25 | Potential. Feature identifier = PRO_5000146696. |
Formula | C118
H175
N31
O36
S4 |
Absent amino acids | ADKLRWY |
Common amino acids | S |
Mass (Da) | 2750.51 |
Net charge | +1 |
Isoelectric point | 6.47 |
Basic residues | 2 |
Acidic residues | 1 |
Hydrophobic residues | 7 |
Polar residues | 12 |
Aliphatic residues | 4 |
Tiny residues | 6 |
Boman Index | -12.12 |
Hydropathy Index | 0.45 |
Aliphatic Index | 54.4 |
Instability Index | 36.05 (stable) |
Half Life |
Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour |
Extinction Coefficient | 125 M-1 cm-1 |
Absorbance 280nm | 5.21 |
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