Bacteriocin: Variacin

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Bacteriocin: Variacin

Accession: BAC028

Classification

Class: Lantibiotic, Type A

Genetics

Gene: ~~Unidentified~~

Producer and target organisms

Producer Organism: Micrococcus varians [Gram-positive]

Taxonomy: BacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeKocuria

Target organismsLactobacillus helveticus - Lactobacillus bulgaricus - Lactobacillus lactis - Lactobacillus delbrueckii - Lactobacillus acidophilus - Lactobacillus plantarum - Lactobacillus sakei (LSK) - Lactobacillus curvatus - Leuconostoc mesenteroides - Streptococcus thermophilus - Lactococcus lactis (SL2) - Micrococcus varians (MCV8) - Micrococcus varians (MCV12) - Enterococcus faecalis - Enterococcus faecium - Listeria innocua - Listeria monocytogenes - Listeria welhia - Clostridium botulinum - Clostridium sp - Staphylococcus aureus - Staphylococcus carnosus - Staphylococcus saprophyticus - Staphylococcus sp - Bacillus subtilis - Bacillus cereus - Bacillus pumilis -

Note: Inactive against Gram-negative bacteria

Description

Mode of action:
Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.

Uniprot and PDB links

UniProt Entry: Q50848

PDB Entry~~Unknown~~

[Ref. 1] | View abstract | Export citation

NUCLEOTIDE SEQUENCE.
MEDLINE=96209245;PubMed=8633879;
Pridmore D., Rekhif N., Pittet A.C., Suri B., Mollet B.
"Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to the lacticin 481 of Lactococcus lactis.", Appl. Environ. Microbiol. 62:1799-1802(1996).

[Ref. 2]

NUCLEOTIDE SEQUENCE.
Pridmore R.D.
"", Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.

Gene structure

Gene id	Name	Description	Location
BACGene90		bacteriocin	88..231

Protein sequence

........10 ........20 ........30
| | |
GSGVIPTISH ECHMNSFQFV FTCCS

Wheel representation

Protein sequence annotations

Feature	Position(s)	Length	Description
CHAIN	1↔25	25	Potential. Feature identifier = PRO_5000146696.

Composition

Hydrophobicity

Composition

Formula	C₁₁₈ H₁₇₅ N₃₁ O₃₆ S₄
Absent amino acids	ADKLRWY
Common amino acids	S
Mass (Da)	2750.51
Net charge	+1
Isoelectric point	6.47
Basic residues	2
Acidic residues	1
Hydrophobic residues	7
Polar residues	12
Aliphatic residues	4
Tiny residues	6
Boman Index	-12.12
Hydropathy Index	0.45
Aliphatic Index	54.4
Instability Index	36.05 (stable)
Half Life	Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour
Extinction Coefficient	125 M^-1 cm^-1
Absorbance 280nm	5.21

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