Bacteriocin: Butyrivibriocin OR79
Accession: BAC026
Classification
Class: Lantibiotic
Genetics
Gene: bvi79; Synonyms=bviA
Producer and target organisms
Producer Organism: Butyrivibrio fibrisolvens [Gram-negative]
Taxonomy: Bacteria
FirmicutesClostridiaClostridialesLachnospiraceaeButyrivibrio
Target organismsButyrivibrio fibrisolvens - Butyrivibrio crossotus - Clostridium clostridiforme - Lachnospira multiparus - Ruminococcus flavefaciens
Description
Mode of action:
Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.
Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.
Uniprot and PDB links
UniProt Entry: O85355
PDB EntryUnknown
NUCLEOTIDE SEQUENCE.
MEDLINE=99240441;PubMed=10224011;
Kalmokoff M.L., Lu D., Whitford M.F., Teather R.M.
"Evidence for production of a new lantibiotic (butyrivibriocin OR79A) by the ruminal anaerobe Butyrivibrio fibrisolvens OR79: characterization of the structural gene encoding butyrivibriocin OR79A.", Appl. Environ. Microbiol. 65:2128-2135(1999).
MEDLINE=99240441;PubMed=10224011;
Kalmokoff M.L., Lu D., Whitford M.F., Teather R.M.
"Evidence for production of a new lantibiotic (butyrivibriocin OR79A) by the ruminal anaerobe Butyrivibrio fibrisolvens OR79: characterization of the structural gene encoding butyrivibriocin OR79A.", Appl. Environ. Microbiol. 65:2128-2135(1999).
[Ref. 2]
NUCLEOTIDE SEQUENCE, STRAIN=OB236
Whitford M.F., McPherson M.A., Forster R.J., Teather R.M.
"", Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Whitford M.F., McPherson M.A., Forster R.J., Teather R.M.
"", Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
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Gene structure
| Gene id | Name | Description | Location |
| BACGene84 | unknown ORF1 | 1..160 | |
| BACGene85 | unknown ORF2 | 157..876 | |
| BACGene86 | unknown ORF3 | 886..1635 | |
| BACGene87 | unknown ORF4 | 1638..1928 | |
| BACGene88 | bvi79 | butyrivibriocin OR79 | 2044..2190 |
| BACGene89 | bvi79 | unknown ORF6 | 2355..4733 |
Protein sequence
| ........10 ........20 ........30 | | | GNGVIKTISH ECHMNTWQFI FTCCS |
Wheel representation
Composition
Hydrophobicity
Composition
| Formula | C124
H186
N34
O36
S4 |
| Absent amino acids | ADLPRY |
| Common amino acids | CIT |
| Mass (Da) | 2875.7 |
| Net charge | +2 |
| Isoelectric point | 7.35 |
| Basic residues | 3 |
| Acidic residues | 1 |
| Hydrophobic residues | 7 |
| Polar residues | 12 |
| Aliphatic residues | 4 |
| Tiny residues | 4 |
| Boman Index | -19.85 |
| Hydropathy Index | 0.12 |
| Aliphatic Index | 58.4 |
| Instability Index | 14.99 (stable) |
| Half Life |
Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 5625 M-1 cm-1 |
| Absorbance 280nm | 234.38 |
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