Bacteriocin: Butyrivibriocin OR79

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Bacteriocin: Butyrivibriocin OR79

Accession: BAC026

Classification
Class: Lantibiotic
Genetics
Gene: bvi79; Synonyms=bviA
Description
Mode of action:
Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.
Uniprot and PDB links

UniProt Entry: O85355

PDB EntryUnknown

NUCLEOTIDE SEQUENCE.
MEDLINE=99240441;PubMed=10224011;
Kalmokoff M.L., Lu D., Whitford M.F., Teather R.M.
"Evidence for production of a new lantibiotic (butyrivibriocin OR79A) by the ruminal anaerobe Butyrivibrio fibrisolvens OR79: characterization of the structural gene encoding butyrivibriocin OR79A.", Appl. Environ. Microbiol. 65:2128-2135(1999).
NUCLEOTIDE SEQUENCE, STRAIN=OB236
Whitford M.F., McPherson M.A., Forster R.J., Teather R.M.
"", Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
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Gene structure
genome of Butyrivibriocin OR79

Gene idNameDescriptionLocation
BACGene84unknown ORF11..160
BACGene85unknown ORF2157..876
BACGene86unknown ORF3886..1635
BACGene87unknown ORF41638..1928
BACGene88bvi79butyrivibriocin OR792044..2190
BACGene89bvi79unknown ORF62355..4733
bvi79bvi79
Protein sequence
 ........10 ........20 ........30 
          |          |          | 
 GNGVIKTISH ECHMNTWQFI FTCCS

Wheel representation
wheel representation of Butyrivibriocin OR79
Composition
Hydrophobicity

Composition
Formula C124 H186 N34 O36 S4
Absent amino acids ADLPRY
Common amino acids CIT
Mass (Da) 2875.7
Net charge +2
Isoelectric point 7.35
Basic residues 3
Acidic residues 1
Hydrophobic residues 7
Polar residues 12
Aliphatic residues 4
Tiny residues 4
Boman Index -19.85
Hydropathy Index 0.12
Aliphatic Index 58.4
Instability Index 14.99 (stable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 5625 M-1 cm-1
Absorbance 280nm 234.38

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