Bacteriocin: plantaricin-A
Accession: BAC022
Classification
Class: Unclassified
Genetics
Gene: plnA; OrderedLocusNames=lp_0415
Producer and target organisms
Producer Organism: Lactobacillus plantarum [Gram-positive]
Taxonomy: BacteriaFirmicutes
Lactobacillales
Lactobacillaceae
Lactobacillus
Target organismsclosely related Lactobacillus {species}
Description
Mode of action:
This heat stable bacteriocin, may act as a pore- forming protein, creating a channel in the cell membrane through a "barrel stave" mechanism. beta chain.
This heat stable bacteriocin, may act as a pore- forming protein, creating a channel in the cell membrane through a "barrel stave" mechanism. beta chain.
Uniprot and PDB links
UniProt Entry: P80214
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=C11
MEDLINE=94161498;PubMed=8117074;
Diep B.D., Havarstein L.S., Nissen-Meyer J., Nes F.I.
"The gene encoding plantaricin A, a bacteriocin from Lactobacillus plantarum C11, is located on the same transcription unit as an agr- like regulatory system.", Appl. Environ. Microbiol. 60:160-166(1994).
MEDLINE=94161498;PubMed=8117074;
Diep B.D., Havarstein L.S., Nissen-Meyer J., Nes F.I.
"The gene encoding plantaricin A, a bacteriocin from Lactobacillus plantarum C11, is located on the same transcription unit as an agr- like regulatory system.", Appl. Environ. Microbiol. 60:160-166(1994).
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=C11
MEDLINE=96345611;PubMed=8755874;
Diep D.B., Havarstein L.S., Nes I.F.
"Characterization of the locus responsible for the bacteriocin production in Lactobacillus plantarum C11.", J. Bacteriol. 178:4472-4483(1996).
MEDLINE=96345611;PubMed=8755874;
Diep D.B., Havarstein L.S., Nes I.F.
"Characterization of the locus responsible for the bacteriocin production in Lactobacillus plantarum C11.", J. Bacteriol. 178:4472-4483(1996).
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], STRAIN=NCIMB 8826 / WCFS1
MEDLINE=22480296;PubMed=12566566;DOI=10.1073/pnas.0337704100
Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing
"Complete genome sequence of Lactobacillus plantarum WCFS1", Proc. Natl. Acad. Sci. U.S.A. 100 (4):1990-5 (2003).
MEDLINE=22480296;PubMed=12566566;DOI=10.1073/pnas.0337704100
Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing
"Complete genome sequence of Lactobacillus plantarum WCFS1", Proc. Natl. Acad. Sci. U.S.A. 100 (4):1990-5 (2003).
PROTEIN SEQUENCE OF 26-47, STRAIN=C11
MEDLINE=94065628;PubMed=8245827;
Nissen-Meyer J., Granly Larsen A.G., Sletten K., Daeschel M., Nes I.F.
"Purification and characterization of plantaricin A, a Lactobacillus plantarum bacteriocin whose activity depends on the action of two peptides.", J. Gen. Microbiol. 139:1973-1978(1993).
MEDLINE=94065628;PubMed=8245827;
Nissen-Meyer J., Granly Larsen A.G., Sletten K., Daeschel M., Nes I.F.
"Purification and characterization of plantaricin A, a Lactobacillus plantarum bacteriocin whose activity depends on the action of two peptides.", J. Gen. Microbiol. 139:1973-1978(1993).
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Gene structure
Gene id | Name | Description | Location |
BACGene62 | plnR | plantaricin biosynthesis protein PlnR | complement(365826..365978) |
BACGene63 | plnO | plantaricin biosynthesis protein PlnO | 368514..369713 |
BACGene64 | plnP | plantaricin biosynthesis protein (pseudogene) | 370693..370728 |
BACGene65 | plnQ | plantaricin biosynthesis protein PlnQ | 370844..371032 |
BACGene66 | plnA | plantaricin A precursor peptide, induction factor | 371368..371514 |
BACGene67 | plnS | plantaricin biosynthesis protein PlnS | 380068..380367 |
Protein sequence
........10 ........20 ........30 | | | AYSLQMGATA IKQVKKLFKK WGW |
Wheel representation
3D Structure
Protein sequence annotations
Feature | Position(s) | Length | Description |
PEPTIDE | 1↔23 | 23 | Bacteriocin plantaricin-A. Feature identifier = PRO_0000002777. |
VARIANT | 1 | Missing (in the alpha chain). | |
STRAND | 6↔8 | 3 | |
HELIX | 9↔18 | 10 |
Composition
Hydrophobicity
Composition
Formula | C128
H200
N32
O29
S1 |
Absent amino acids | CDEHNPR |
Common amino acids | K |
Mass (Da) | 2701.64 |
Net charge | +5 |
Isoelectric point | 11.02 |
Basic residues | 5 |
Acidic residues | 0 |
Hydrophobic residues | 10 |
Polar residues | 5 |
Aliphatic residues | 4 |
Tiny residues | 6 |
Boman Index | -8.84 |
Hydropathy Index | -0.24 |
Aliphatic Index | 76.52 |
Instability Index | 12.75 (stable) |
Half Life |
Mammalian : 4.4 hour Yeast : >20 hour E. coli : >10 hour |
Extinction Coefficient | 12490 M-1 cm-1 |
Absorbance 280nm | 567.73 |
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