Bacteriocin: plantaricin-A

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Bacteriocin: plantaricin-A

Accession: BAC022

Classification
Class: Unclassified
Genetics
Gene: plnA; OrderedLocusNames=lp_0415
Producer and target organisms

Producer Organism: Lactobacillus plantarum [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesLactobacillaceaeLactobacillus

Target organismsclosely related Lactobacillus {species}

Description
Mode of action:
This heat stable bacteriocin, may act as a pore- forming protein, creating a channel in the cell membrane through a "barrel stave" mechanism. beta chain.
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=C11
MEDLINE=94161498;PubMed=8117074;
Diep B.D., Havarstein L.S., Nissen-Meyer J., Nes F.I.
"The gene encoding plantaricin A, a bacteriocin from Lactobacillus plantarum C11, is located on the same transcription unit as an agr- like regulatory system.", Appl. Environ. Microbiol. 60:160-166(1994).
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=C11
MEDLINE=96345611;PubMed=8755874;
Diep D.B., Havarstein L.S., Nes I.F.
"Characterization of the locus responsible for the bacteriocin production in Lactobacillus plantarum C11.", J. Bacteriol. 178:4472-4483(1996).
PROTEIN SEQUENCE OF 26-47, STRAIN=C11
MEDLINE=94065628;PubMed=8245827;
Nissen-Meyer J., Granly Larsen A.G., Sletten K., Daeschel M., Nes I.F.
"Purification and characterization of plantaricin A, a Lactobacillus plantarum bacteriocin whose activity depends on the action of two peptides.", J. Gen. Microbiol. 139:1973-1978(1993).
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Gene structure
genome of plantaricin-A

Gene idNameDescriptionLocation
BACGene62plnRplantaricin biosynthesis protein PlnRcomplement(365826..365978)
BACGene63plnOplantaricin biosynthesis protein PlnO368514..369713
BACGene64plnPplantaricin biosynthesis protein (pseudogene)370693..370728
BACGene65plnQplantaricin biosynthesis protein PlnQ370844..371032
BACGene66plnAplantaricin A precursor peptide, induction factor371368..371514
BACGene67plnSplantaricin biosynthesis protein PlnS380068..380367
plnRplnOplnPplnQplnAplnS
Protein sequence
 ........10 ........20 ........30 
          |          |          | 
 AYSLQMGATA IKQVKKLFKK WGW

Wheel representation
wheel representation of plantaricin-A
3D Structure
Protein sequence annotations
Features of plantaricin-A


FeaturePosition(s)LengthDescription
PEPTIDE1↔2323
Bacteriocin plantaricin-A.
Feature identifier = PRO_0000002777.
VARIANT1Missing (in the alpha chain).
STRAND6↔83
HELIX9↔1810
Composition
Hydrophobicity

Composition
Formula C128 H200 N32 O29 S1
Absent amino acids CDEHNPR
Common amino acids K
Mass (Da) 2701.64
Net charge +5
Isoelectric point 11.02
Basic residues 5
Acidic residues 0
Hydrophobic residues 10
Polar residues 5
Aliphatic residues 4
Tiny residues 6
Boman Index -8.84
Hydropathy Index -0.24
Aliphatic Index 76.52
Instability Index 12.75 (stable)
Half Life Mammalian : 4.4 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 12490 M-1 cm-1
Absorbance 280nm 567.73

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