Bacteriocin: streptin
Accession: BAC021
Classification
Class: lantibiotic
Genetics
Gene: srtA
Producer and target organisms
Producer Organism: Streptococcus pyogenes [Gram-positive]
Taxonomy: Bacteria
FirmicutesLactobacillalesStreptococcaceaeStreptococcus
Description
Mode of action:
Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor (By similarity). acids at the N-terminus) is probably due to incomplete processing. Other forms also exist, some of which are due to differing levels of dehydration.
Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor (By similarity). acids at the N-terminus) is probably due to incomplete processing. Other forms also exist, some of which are due to differing levels of dehydration.
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=BL-T
MEDLINE=21226666;PubMed=11328600;
Karaya K., Shimizu T., Taketo A.
"New gene cluster for lantibiotic streptin possibly involved in streptolysin S formation.", J. Biochem. 129:769-775(2001).
MEDLINE=21226666;PubMed=11328600;
Karaya K., Shimizu T., Taketo A.
"New gene cluster for lantibiotic streptin possibly involved in streptolysin S formation.", J. Biochem. 129:769-775(2001).
PROTEIN SEQUENCE OF 21-29, AND CHARACTERIZATION OF ANTIBIOTIC ACTIVITY, STRAIN=M25
MEDLINE=22617465;PubMed=12732544;DOI=10.1128/AEM.69.5.2737-2747.2003
Wescombe P.A., Tagg J.R.
"Purification and characterization of streptin, a type A1 lantibiotic produced by Streptococcus pyogenes.", Appl. Environ. Microbiol. 69:2737-2747(2003).
MEDLINE=22617465;PubMed=12732544;DOI=10.1128/AEM.69.5.2737-2747.2003
Wescombe P.A., Tagg J.R.
"Purification and characterization of streptin, a type A1 lantibiotic produced by Streptococcus pyogenes.", Appl. Environ. Microbiol. 69:2737-2747(2003).
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Gene structure
| Gene id | Name | Description | Location |
| BACGene52 | srtI | SrtI | 253..570 |
| BACGene53 | srtR | SrtR | 721..1407 |
| BACGene54 | srtK | SrtK | 1400..2746 |
| BACGene55 | srtA | SrtA latibiotics precursor | 2903..3043 |
| BACGene56 | srtT | SrtT | 3158..4948 |
| BACGene57 | srtC | SrtC | 4932..6176 |
| BACGene58 | srtB | SrtB | 6195..9161 |
| BACGene59 | srtF | SrtF | 9167..9856 |
| BACGene60 | srtE | SrtE | 9862..10611 |
| BACGene61 | srtG | SrtG | 10614..11336 |
Protein sequence
| ........10 ........20 ........30 | | | GSRYLCTPGS CWKLVCFTTT VK |
Wheel representation
Protein sequence annotations
| Feature | Position(s) | Length | Description |
| PEPTIDE | 1↔22 | 22 | Lantibiotic streptin. Feature identifier = PRO_0000017139. |
Composition
Hydrophobicity
Composition
| Formula | C109
H172
N28
O30
S3 |
| Absent amino acids | ADEHIMNQ |
| Common amino acids | T |
| Mass (Da) | 2469.26 |
| Net charge | +3 |
| Isoelectric point | 8.95 |
| Basic residues | 3 |
| Acidic residues | 0 |
| Hydrophobic residues | 6 |
| Polar residues | 12 |
| Aliphatic residues | 4 |
| Tiny residues | 4 |
| Boman Index | -14.29 |
| Hydropathy Index | 0.23 |
| Aliphatic Index | 61.82 |
| Instability Index | 50.1 (unstable) |
| Half Life |
Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 7115 M-1 cm-1 |
| Absorbance 280nm | 338.81 |
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