Bacteriocin: ancovenin

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Bacteriocin: ancovenin

Accession: BAC013

Classification
Class: Lantibiotic
Genetics
Gene: Unidentified
Producer and target organisms

Producer Organism: Streptomyces sp (strain A647P-2) [Gram-positive]

Taxonomy: BacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Target organismsUnavailable data

Description
Mode of action:
Acts as an inhibitor of angiotensin I converting enzyme.

Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine or the formation of dialkylamine bonds with lysine. This is followed by membrane translocation and cleavage of the modified precursor.
Uniprot and PDB links

UniProt Entry: P38655

PDB EntryUnknown

PROTEIN SEQUENCE.
Wakamiya T., Ueki Y., Shiba T., Kido Y., Motoki Y.
"The structure of ancovenin, a new peptide inhibitor of angiotensin I converting enzyme.", Tetrahedron Lett. 26:665-668(1985).
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Protein sequence
 ........10 ........20 
          |          | 
 CVQSCSFGPL TWSCDGNTK

Wheel representation
wheel representation of ancovenin
Protein sequence annotations
Features of ancovenin


FeaturePosition(s)LengthDescription
PEPTIDE1↔1919
Lantibiotic ancovenin.
Feature identifier = PRO_0000043968.
Cross-link1↔1818Beta-methyllanthionine (Cys-Thr).
Cross-link4↔1411Lanthionine (Ser-Cys).
Cross-link5↔117Beta-methyllanthionine (Cys-Thr).
Cross-link6↔1914Lysinoalanine (Ser-Lys).
Composition
Hydrophobicity

Composition
Formula C85 H129 N23 O29 S3
Absent amino acids AEHIMRY
Common amino acids CS
Mass (Da) 2051.58
Net charge 0
Isoelectric point 6
Basic residues 1
Acidic residues 1
Hydrophobic residues 4
Polar residues 11
Aliphatic residues 2
Tiny residues 5
Boman Index -21.8
Hydropathy Index -0.17
Aliphatic Index 35.79
Instability Index 56.24 (unstable)
Half Life Mammalian : 1.2 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 5625 M-1 cm-1
Absorbance 280nm 312.5

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