Bacteriocin: ancovenin
Accession: BAC013
Classification
Class: Lantibiotic
Genetics
Gene: Unidentified
Producer and target organisms
Producer Organism: Streptomyces sp (strain A647P-2) [Gram-positive]
Taxonomy: Bacteria
ActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
Target organismsUnavailable data
Description
Mode of action:
Acts as an inhibitor of angiotensin I converting enzyme.
Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine or the formation of dialkylamine bonds with lysine. This is followed by membrane translocation and cleavage of the modified precursor.
Acts as an inhibitor of angiotensin I converting enzyme.
Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine or the formation of dialkylamine bonds with lysine. This is followed by membrane translocation and cleavage of the modified precursor.
Uniprot and PDB links
UniProt Entry: P38655
PDB EntryUnknown
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Protein sequence
| ........10 ........20 | | CVQSCSFGPL TWSCDGNTK |
Wheel representation
Protein sequence annotations
| Feature | Position(s) | Length | Description |
| PEPTIDE | 1↔19 | 19 | Lantibiotic ancovenin. Feature identifier = PRO_0000043968. |
| Cross-link | 1↔18 | 18 | Beta-methyllanthionine (Cys-Thr). |
| Cross-link | 4↔14 | 11 | Lanthionine (Ser-Cys). |
| Cross-link | 5↔11 | 7 | Beta-methyllanthionine (Cys-Thr). |
| Cross-link | 6↔19 | 14 | Lysinoalanine (Ser-Lys). |
Composition
Hydrophobicity
Composition
| Formula | C85
H129
N23
O29
S3 |
| Absent amino acids | AEHIMRY |
| Common amino acids | CS |
| Mass (Da) | 2051.58 |
| Net charge | 0 |
| Isoelectric point | 6 |
| Basic residues | 1 |
| Acidic residues | 1 |
| Hydrophobic residues | 4 |
| Polar residues | 11 |
| Aliphatic residues | 2 |
| Tiny residues | 5 |
| Boman Index | -21.8 |
| Hydropathy Index | -0.17 |
| Aliphatic Index | 35.79 |
| Instability Index | 56.24 (unstable) |
| Half Life |
Mammalian : 1.2 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 5625 M-1 cm-1 |
| Absorbance 280nm | 312.5 |
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