Bacteriocin: duramycin-C

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Bacteriocin: duramycin-C

Accession: BAC011

Classification
Class: Lantibiotic
Genetics
Gene: Unidentified
Description
Mode of action:
Acts as inhibitor of phospholipase A2.

Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine or the formation of dialkylamine bonds with lysine. This is followed by membrane translocation and cleavage of the modified precursor.
Uniprot and PDB links

UniProt Entry: P36503

PDB EntryUnknown

PROTEIN SEQUENCE OF 60-78.
MEDLINE=91107436;PubMed=2125590;
Fredenhagen A., Fendrich G., Marki F., Marki W., Gruner J., Raschdorf F., Peter H.H.
"Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin.", J. Antibiot. 43:1403-1412(1990).
STRUCTURE BY NMR.
Zimmermann N., Freund S., Fredenhagen A., Jung G.
"Solution structure of the lantibiotics duramycin B and C.",
STRUCTURE BY NMR.
MEDLINE=93387292;PubMed=8375380;
Zimmermann N., Freund S., Fredenhagen A., Jung G.
"Solution structures of the lantibiotics duramycin B and C.", Eur. J. Biochem. 216:419-428(1993).
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Protein sequence
 ........10 ........20 
          |          | 
 CANSCSYGPL TWSCDGNTK

Wheel representation
wheel representation of duramycin-C
Protein sequence annotations
Features of duramycin-C


FeaturePosition(s)LengthDescription
PEPTIDE1↔1919
Lantibiotic duramycin-C.
Feature identifier = PRO_0000043972.
Cross-link1↔1818Beta-methyllanthionine (Cys-Thr).
Cross-link4↔1411Lanthionine (Ser-Cys).
Cross-link5↔117Beta-methyllanthionine (Cys-Thr).
Cross-link6↔1914Lysinoalanine (Ser-Lys).
Composition
Hydrophobicity

Composition
Formula C82 H123 N23 O30 S3
Absent amino acids EFHIMQRV
Common amino acids CS
Mass (Da) 2025.5
Net charge 0
Isoelectric point 6
Basic residues 1
Acidic residues 1
Hydrophobic residues 3
Polar residues 13
Aliphatic residues 1
Tiny residues 6
Boman Index -28.25
Hydropathy Index -0.51
Aliphatic Index 25.79
Instability Index 32.61 (stable)
Half Life Mammalian : 1.2 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 7115 M-1 cm-1
Absorbance 280nm 395.28

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