Bacteriocin: duramycin-C
Accession: BAC011
Classification
Class: Lantibiotic
Genetics
Gene: Unidentified
Producer and target organisms
Producer Organism: Streptomyces griseoluteus [Gram-positive]
Taxonomy: Bacteria
ActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
Target organismsBacillus
Description
Mode of action:
Acts as inhibitor of phospholipase A2.
Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine or the formation of dialkylamine bonds with lysine. This is followed by membrane translocation and cleavage of the modified precursor.
Acts as inhibitor of phospholipase A2.
Post-translational modification:
Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine or the formation of dialkylamine bonds with lysine. This is followed by membrane translocation and cleavage of the modified precursor.
Uniprot and PDB links
UniProt Entry: P36503
PDB EntryUnknown
PROTEIN SEQUENCE OF 60-78.
MEDLINE=91107436;PubMed=2125590;
Fredenhagen A., Fendrich G., Marki F., Marki W., Gruner J., Raschdorf F., Peter H.H.
"Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin.", J. Antibiot. 43:1403-1412(1990).
MEDLINE=91107436;PubMed=2125590;
Fredenhagen A., Fendrich G., Marki F., Marki W., Gruner J., Raschdorf F., Peter H.H.
"Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin.", J. Antibiot. 43:1403-1412(1990).
[Ref. 2]
STRUCTURE BY NMR.
Zimmermann N., Freund S., Fredenhagen A., Jung G.
"Solution structure of the lantibiotics duramycin B and C.",
Zimmermann N., Freund S., Fredenhagen A., Jung G.
"Solution structure of the lantibiotics duramycin B and C.",
STRUCTURE BY NMR.
MEDLINE=93387292;PubMed=8375380;
Zimmermann N., Freund S., Fredenhagen A., Jung G.
"Solution structures of the lantibiotics duramycin B and C.", Eur. J. Biochem. 216:419-428(1993).
MEDLINE=93387292;PubMed=8375380;
Zimmermann N., Freund S., Fredenhagen A., Jung G.
"Solution structures of the lantibiotics duramycin B and C.", Eur. J. Biochem. 216:419-428(1993).
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Protein sequence
| ........10 ........20 | | CANSCSYGPL TWSCDGNTK |
Wheel representation
Protein sequence annotations
| Feature | Position(s) | Length | Description |
| PEPTIDE | 1↔19 | 19 | Lantibiotic duramycin-C. Feature identifier = PRO_0000043972. |
| Cross-link | 1↔18 | 18 | Beta-methyllanthionine (Cys-Thr). |
| Cross-link | 4↔14 | 11 | Lanthionine (Ser-Cys). |
| Cross-link | 5↔11 | 7 | Beta-methyllanthionine (Cys-Thr). |
| Cross-link | 6↔19 | 14 | Lysinoalanine (Ser-Lys). |
Composition
Hydrophobicity
Composition
| Formula | C82
H123
N23
O30
S3 |
| Absent amino acids | EFHIMQRV |
| Common amino acids | CS |
| Mass (Da) | 2025.5 |
| Net charge | 0 |
| Isoelectric point | 6 |
| Basic residues | 1 |
| Acidic residues | 1 |
| Hydrophobic residues | 3 |
| Polar residues | 13 |
| Aliphatic residues | 1 |
| Tiny residues | 6 |
| Boman Index | -28.25 |
| Hydropathy Index | -0.51 |
| Aliphatic Index | 25.79 |
| Instability Index | 32.61 (stable) |
| Half Life |
Mammalian : 1.2 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 7115 M-1 cm-1 |
| Absorbance 280nm | 395.28 |
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