Bacteriocin: Halocin-C8
Accession: BAC008
Classification
Class: Unclassified
Genetics
Gene: Unidentified
Producer and target organisms
Producer Organism: Halobacterium sp (strain AS7092) [Gram-]
Taxonomy: Archaea
EuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium
Target organismswide variety of haloarchaeons
Description
Mode of action:
Causes cell lysis and death, possibly by disrupting the cell wall. boiled, subjected to organic solvents, and stored at 4 degrees Celsius for extended periods without losing activity.
Causes cell lysis and death, possibly by disrupting the cell wall. boiled, subjected to organic solvents, and stored at 4 degrees Celsius for extended periods without losing activity.
Uniprot and PDB links
UniProt Entry: P83716
PDB EntryUnknown
PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=12811620;DOI=10.1007/s00792-003-0335-6
Li Y., Xiang H., Liu J., Zhou M., Tan H.
"Purification and biological characterization of halocin C8, a novel peptide antibiotic from Halobacterium strain AS7092.", Extremophiles 7:401-407(2003).
PubMed=12811620;DOI=10.1007/s00792-003-0335-6
Li Y., Xiang H., Liu J., Zhou M., Tan H.
"Purification and biological characterization of halocin C8, a novel peptide antibiotic from Halobacterium strain AS7092.", Extremophiles 7:401-407(2003).
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Gene structure
| Gene id | Name | Description | Location |
| BACGene1 | halU | transmembrane protein | 1158..2762 |
| BACGene2 | halR | transcriptional regulator HalR; putative | 3293..4102 |
| BACGene3 | proC8 | halocin C8 precursor preproprotein | 4330..5181 |
| BACGene4 | halT1 | permease protein | complement(5282..6250) |
| BACGene5 | halT2 | periplasmic protein | 6512..7591 |
| BACGene6 | halT3 | ABC transporter integral membrane protein | 7722..9372 |
Protein sequence
| ........10 ........20 | | DIDITGCSAC KYAAG |
Wheel representation
Protein sequence annotations
| Feature | Position(s) | Length | Description |
| CHAIN | 1 | Halocin-C8. Feature identifier = PRO_0000195165. | |
| NON_TER | 15 |
Composition
Hydrophobicity
Composition
| Formula | C61
H98
N16
O23
S2 |
| Absent amino acids | EFHLMNPQRVW |
| Common amino acids | A |
| Mass (Da) | 1505.93 |
| Net charge | -1 |
| Isoelectric point | 4.11 |
| Basic residues | 1 |
| Acidic residues | 2 |
| Hydrophobic residues | 5 |
| Polar residues | 7 |
| Aliphatic residues | 2 |
| Tiny residues | 6 |
| Boman Index | -9.39 |
| Hydropathy Index | 0.33 |
| Aliphatic Index | 72 |
| Instability Index | 48.75 (unstable) |
| Half Life |
Mammalian : 1.1 hour Yeast : 3 min E. coli : >10 hour |
| Extinction Coefficient | 1615 M-1 cm-1 |
| Absorbance 280nm | 115.36 |
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