Bacteriocin: Halocin-C8

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Bacteriocin: Halocin-C8

Accession: BAC008

Classification
Class: Unclassified
Genetics
Gene: Unidentified
Producer and target organisms

Producer Organism: Halobacterium sp (strain AS7092) [Gram-]

Taxonomy: ArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Target organismswide variety of haloarchaeons

Description
Mode of action:
Causes cell lysis and death, possibly by disrupting the cell wall. boiled, subjected to organic solvents, and stored at 4 degrees Celsius for extended periods without losing activity.
Uniprot and PDB links

UniProt Entry: P83716

PDB EntryUnknown

PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=12811620;DOI=10.1007/s00792-003-0335-6
Li Y., Xiang H., Liu J., Zhou M., Tan H.
"Purification and biological characterization of halocin C8, a novel peptide antibiotic from Halobacterium strain AS7092.", Extremophiles 7:401-407(2003).
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End Note
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Gene structure
genome of Halocin-C8

Gene idNameDescriptionLocation
BACGene1halUtransmembrane protein1158..2762
BACGene2halRtranscriptional regulator HalR; putative3293..4102
BACGene3proC8halocin C8 precursor preproprotein4330..5181
BACGene4halT1permease proteincomplement(5282..6250)
BACGene5halT2periplasmic protein6512..7591
BACGene6halT3ABC transporter integral membrane protein7722..9372
halUhalRproC8halT1halT2halT3
Protein sequence
 ........10 ........20 
          |          | 
 DIDITGCSAC KYAAG

Wheel representation
wheel representation of Halocin-C8
Protein sequence annotations
Features of Halocin-C8


FeaturePosition(s)LengthDescription
CHAIN1
Halocin-C8.
Feature identifier = PRO_0000195165.
NON_TER15
Composition
Hydrophobicity

Composition
Formula C61 H98 N16 O23 S2
Absent amino acids EFHLMNPQRVW
Common amino acids A
Mass (Da) 1505.93
Net charge -1
Isoelectric point 4.11
Basic residues 1
Acidic residues 2
Hydrophobic residues 5
Polar residues 7
Aliphatic residues 2
Tiny residues 6
Boman Index -9.39
Hydropathy Index 0.33
Aliphatic Index 72
Instability Index 48.75 (unstable)
Half Life Mammalian : 1.1 hour
Yeast : 3 min
E. coli : >10 hour
Extinction Coefficient 1615 M-1 cm-1
Absorbance 280nm 115.36

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